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    Ism1 isthmin 1, angiogenesis inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 319909, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Ism1provided by MGI
    Official Full Name
    isthmin 1, angiogenesis inhibitorprovided by MGI
    Primary source
    MGI:MGI:2442963
    See related
    Ensembl:ENSMUSG00000074766 AllianceGenome:MGI:2442963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ism; 5430433G21Rik
    Summary
    Involved in negative regulation of angiogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including brain; eye; immune system; limb long bone; and lung. Orthologous to human ISM1 (isthmin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 22.8), adrenal adult (RPKM 12.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ism1 in Genome Data Viewer
    Location:
    2 F3; 2 69.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (139515169..139600500)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (139673359..139758581)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ADP/ATP translocase 2 pseudogene Neighboring gene serine palmitoyltransferase, long chain base subunit 3 Neighboring gene STARR-seq mESC enhancer starr_05833 Neighboring gene STARR-seq mESC enhancer starr_05835 Neighboring gene STARR-seq mESC enhancer starr_05836 Neighboring gene STARR-seq mESC enhancer starr_05837 Neighboring gene STARR-seq mESC enhancer starr_05838 Neighboring gene STARR-seq mESC enhancer starr_05839 Neighboring gene taspase, threonine aspartase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139750776-139750959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139760469-139760763 Neighboring gene STARR-positive B cell enhancer mm9_chr2:139792158-139792459 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139867947-139868134 Neighboring gene STARR-positive B cell enhancer ABC_E4503 Neighboring gene ribosomal protein S19, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice. Tee JH, et al. Respir Res, 2023 Nov 6. PMID 37932719, Free PMC Article
    2. Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1. Zhao M, et al. Elife, 2022 Sep 28. PMID 36169399, Free PMC Article
    3. ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice. Nguyen N, et al. Mol Med, 2022 Jun 25. PMID 35752760, Free PMC Article
    4. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis. Lam TYW, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35046017, Free PMC Article
    5. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Jiang Z, et al. Cell Metab, 2021 Sep 7. PMID 34348115, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The paracrine isthmin1 transcriptionally regulated by C/EBPbeta exacerbates pulmonary vascular leakage in murine sepsis.
      Title: The paracrine isthmin1 transcriptionally regulated by C/EBPβ exacerbates pulmonary vascular leakage in murine sepsis.
    2. Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
      Title: Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.
    3. Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
      Title: Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
    4. Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
      Title: Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
    5. ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.
      Title: ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice.
    6. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
      Title: Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
    7. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.
      Title: ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.
    8. Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.
      Title: Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.
    9. ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis
      Title: Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation.
    10. ISM1 transcripts are found in tissues as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain.
      Title: Distinct spatiotemporal expression of ISM1 during mouse and chick development.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • RP23-296P2.1, 5430433G21Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isthmin-1
    Names
    isthmin 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276489.2 → NP_001263418.1  isthmin-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928831
      Consensus CDS
      CCDS50730.2
      UniProtKB/Swiss-Prot
      A2ATD1
      UniProtKB/TrEMBL
      V9GXR4
      Related
      ENSMUSP00000139280.2, ENSMUST00000184404.8
      Conserved Domains (2) summary
      smart00723
      Location:286 → 449
      AMOP; Adhesion-associated domain present in MUC4 and other proteins
      smart00209
      Location:218 → 259
      TSP1; Thrombospondin type 1 repeats

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      139515169..139600500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162293.1 → XP_036018186.1  isthmin-1 isoform X2

      Conserved Domains (1) summary
      smart00209
      Location:218 → 259
      TSP1; Thrombospondin type 1 repeats

    2. XM_036162292.1 → XP_036018185.1  isthmin-1 isoform X1

      Conserved Domains (1) summary
      smart00209
      Location:218 → 259
      TSP1; Thrombospondin type 1 repeats

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001126490.1: Suppressed sequence

      Description
      NM_001126490.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ATD1.1 GenPept UniProtKB/Swiss-Prot:A2ATD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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