Cytl1 cytokine-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cytl1provided by MGI
Official Full Name: cytokine-like 1provided by MGI
Primary source: MGI:MGI:2684993
See related: Ensembl:ENSMUSG00000062329 AllianceGenome:MGI:2684993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C17; Cyt1; Gm147; 4Cytl1; 4930443F05Rik
Summary: Acts upstream of or within several processes, including cartilage homeostasis; chondrocyte differentiation; and regulation of DNA-templated transcription. Is expressed in several structures, including forelimb; gut; respiratory system; sensory organ; and skeleton. Orthologous to human CYTL1 (cytokine like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 63.3), heart adult (RPKM 19.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.21 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (37892863..37897164)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (37735519..37739820)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and cartilage metabolism.
Title: The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and cartilage metabolism.
CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model.
Title: CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model.
Results collectively suggest that CYTL1 negatively regulates the osteogenesis of MSCs and positively regulates osteoclastogenesis to modulate bone mass.
Title: CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages.
Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta-SMAD signaling pathway.
Title: Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of TGF-β Signaling.
C17 as a cytokine that s contributes to immune homeostasis systemically or in a tissue-specific manner in the joint
Title: C17 prevents inflammatory arthritis and associated joint destruction in mice.
results suggest that, rather than regulating cartilage and bone development, Cytl1 is required for the maintenance of cartilage homeostasis, and loss of Cytl1 function is associated with experimental OA cartilage destruction in mice
Title: Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction.
chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development
Title: Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493063

Cytl1 (e-PCR), detects polymorphism
- UniSTS:507424

Cytl1 (e-PCR), detects polymorphism
- UniSTS:507425

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: cytokine-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.