Ak5 adenylate kinase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ak5provided by MGI
Official Full Name: adenylate kinase 5provided by MGI
Primary source: MGI:MGI:2677491
See related: Ensembl:ENSMUSG00000039058 AllianceGenome:MGI:2677491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in ATP metabolic process and nucleoside monophosphate phosphorylation. Predicted to be located in centriolar satellite. Predicted to be active in cytosol. Is expressed in alimentary system; cranium; nervous system; and urinary system. Orthologous to human AK5 (adenylate kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 13.7), cortex adult (RPKM 12.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 77.16 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (152168461..152373992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (152462815..152668406, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493059

Ak5 (e-PCR), detects polymorphism
- UniSTS:546642

NoName (e-PCR)
- UniSTS:490584

NoName (e-PCR)
- UniSTS:234847

AI481057 (e-PCR)
- UniSTS:159203

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate kinase isoenzyme 5

Names: ATP-AMP transphosphorylase 5

NP_001074746.1

EC 2.7.4.3

EC 2.7.4.6

NP_001342564.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396656.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396658.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396668.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396669.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396670.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396671.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396672.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396673.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396674.1

EC 2.7.4.3

EC 2.7.4.6

NP_001396675.1

EC 2.7.4.3

EC 2.7.4.6

XP_006501503.1

EC 2.7.4.3

EC 2.7.4.6

XP_011238417.1

EC 2.7.4.3

EC 2.7.4.6

XP_036018982.1

EC 2.7.4.3

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081277.3 → NP_001074746.1 adenylate kinase isoenzyme 5 isoform 1

See identical proteins and their annotated locations for NP_001074746.1

Status: VALIDATED

Source sequence(s)

AC111139, AC116720

Consensus CDS

CCDS38675.1

UniProtKB/Swiss-Prot

Q920P5

Related

ENSMUSP00000042785.7, ENSMUST00000045262.11

Conserved Domains (2) summary

TIGR01360
Location:374 → 561

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

cd01428
Location:378 → 550

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
NM_001355635.2 → NP_001342564.1 adenylate kinase isoenzyme 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC111139, AC116720

Conserved Domains (1) summary

cd01428
Location:134 → 307

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
NM_001409727.1 → NP_001396656.1 adenylate kinase isoenzyme 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409729.1 → NP_001396658.1 adenylate kinase isoenzyme 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409739.1 → NP_001396668.1 adenylate kinase isoenzyme 5 isoform 5

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409740.1 → NP_001396669.1 adenylate kinase isoenzyme 5 isoform 6

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409741.1 → NP_001396670.1 adenylate kinase isoenzyme 5 isoform 7

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409742.1 → NP_001396671.1 adenylate kinase isoenzyme 5 isoform 8

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409743.1 → NP_001396672.1 adenylate kinase isoenzyme 5 isoform 9

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409744.1 → NP_001396673.1 adenylate kinase isoenzyme 5 isoform 10

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409745.1 → NP_001396674.1 adenylate kinase isoenzyme 5 isoform 11

Status: VALIDATED

Source sequence(s)

AC111139, AC116720
NM_001409746.1 → NP_001396675.1 adenylate kinase isoenzyme 5 isoform 12

Status: VALIDATED

Source sequence(s)

AC111139, AC116720

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

152168461..152373992 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163089.1 → XP_036018982.1 adenylate kinase isoenzyme 5 isoform X3

Conserved Domains (2) summary

TIGR01360
Location:374 → 501

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

cd01428
Location:134 → 307

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
XM_011240115.4 → XP_011238417.1 adenylate kinase isoenzyme 5 isoform X1

Conserved Domains (2) summary

TIGR01360
Location:374 → 540

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

cd01428
Location:134 → 307

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
XM_006501440.5 → XP_006501503.1 adenylate kinase isoenzyme 5 isoform X2

Conserved Domains (2) summary

TIGR01360
Location:374 → 540

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

cd01428
Location:134 → 307

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...