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    Zc3h3 zinc finger CCCH type containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 223642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h3provided by MGI
    Official Full Name
    zinc finger CCCH type containing 3provided by MGI
    Primary source
    MGI:MGI:2663721
    See related
    Ensembl:ENSMUSG00000075600 AllianceGenome:MGI:2663721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smicl; Zc3hdc3; Kiaa0150
    Summary
    Enables R-SMAD binding activity. Acts upstream of or within mRNA 3'-end processing and positive regulation of activin receptor signaling pathway. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in central nervous system and genitourinary system. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.7), duodenum adult (RPKM 14.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h3 in Genome Data Viewer
    Location:
    15 D3; 15 34.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75626279..75713772, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75754430..75842061, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10864 Neighboring gene MAF bZIP transcription factor A Neighboring gene predicted gene, 23747 Neighboring gene STARR-positive B cell enhancer ABC_E1911 Neighboring gene STARR-seq mESC enhancer starr_39021 Neighboring gene predicted gene, 34851 Neighboring gene predicted gene, 53897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Collart C, et al. Genes Cells, 2005 Sep. PMID 16115198
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables R-SMAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of activin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 3
    Names
    smad-interacting CPSF-like factor
    zinc finger CCCH type domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416439.1 → NP_001403368.1  zinc finger CCCH domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    2. NM_001416440.1 → NP_001403369.1  zinc finger CCCH domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    3. NM_001416441.1 → NP_001403370.1  zinc finger CCCH domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    4. NM_001416442.1 → NP_001403371.1  zinc finger CCCH domain-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    5. NM_001416443.1 → NP_001403372.1  zinc finger CCCH domain-containing protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116393

    6. NM_001416444.1 → NP_001403373.1  zinc finger CCCH domain-containing protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116393

    7. NM_172121.2 → NP_742119.1  zinc finger CCCH domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_742119.1

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520
      Consensus CDS
      CCDS27550.1
      UniProtKB/Swiss-Prot
      Q80X78, Q8CHP0
      UniProtKB/TrEMBL
      Q3UUL4
      Related
      ENSMUSP00000098106.3, ENSMUST00000100538.4
      Conserved Domains (2) summary
      smart00356
      Location:745 → 771
      ZnF_C3H1; zinc finger
      pfam00642
      Location:663 → 689
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RNA

    1. NR_183921.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    2. NR_183922.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    3. NR_183923.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116393, AC116520

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75626279..75713772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHP0.1 GenPept UniProtKB/Swiss-Prot:Q8CHP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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