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    Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 [ Mus musculus (house mouse) ]

    Gene ID: 102098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef18provided by MGI
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 18provided by MGI
    Primary source
    MGI:MGI:2142567
    See related
    Ensembl:ENSMUSG00000004568 AllianceGenome:MGI:2142567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430078G23Rik; D030053O22Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; genitourinary system; integument; and liver. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 41.5), thymus adult (RPKM 26.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef18 in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3403339..3506601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3353338..3456601)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 88 Neighboring gene insulin receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:3354554-3354663 Neighboring gene predicted gene, 30369 Neighboring gene STARR-seq mESC enhancer starr_20578 Neighboring gene predicted gene, 46029 Neighboring gene STARR-positive B cell enhancer ABC_E10487 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Xu X, et al. Mol Cell Biol, 2013 Jul. PMID 23648482, Free PMC Article
    2. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Tsuji T, et al. Mol Biol Cell, 2010 Oct 15. PMID 20810787, Free PMC Article
    3. The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Schell C, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28536193, Free PMC Article
    4. The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Boglev Y, et al. Dev Biol, 2011 Jan 15. PMID 21081122
    5. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 18
    Names
    rho/rac guanine nucleotide exchange factor (GEF) 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370668.1 → NP_001357597.1  rho guanine nucleotide exchange factor 18 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC169677
      UniProtKB/Swiss-Prot
      E9QK59, Q6A055, Q6P9R4, Q8BYA4, Q8K227
      UniProtKB/TrEMBL
      A0A5F8MPH6
      Related
      ENSMUSP00000158969.2, ENSMUST00000239102.2
      Conserved Domains (4) summary
      cd00160
      Location:486 → 680
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:721 → 839
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1044 → 1165
      DUF5401; Family of unknown function (DUF5401)
      cl28929
      Location:1124 → 1276
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    2. NM_133962.4 → NP_598723.3  rho guanine nucleotide exchange factor 18 isoform 2

      See identical proteins and their annotated locations for NP_598723.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) results from the use of an alternate downstream promoter and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK041423, AK083608, BC060639, BQ830835, CA749983
      Consensus CDS
      CCDS22060.1
      UniProtKB/TrEMBL
      A0A5F8MPF6
      Related
      ENSMUSP00000004684.7, ENSMUST00000004684.13
      Conserved Domains (4) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:667 → 783
      DUF5401; Family of unknown function (DUF5401)
      cl28929
      Location:740 → 892
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3403339..3506601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243210.2 → XP_030099070.1  rho guanine nucleotide exchange factor 18 isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPH6
      Conserved Domains (4) summary
      PRK13729
      Location:1132 → 1284
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:486 → 680
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:721 → 839
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1059 → 1176
      DUF5401; Family of unknown function (DUF5401)

    2. XM_030243212.2 → XP_030099072.1  rho guanine nucleotide exchange factor 18 isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPH6
      Conserved Domains (4) summary
      PRK13729
      Location:1071 → 1223
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:425 → 619
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:660 → 778
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:998 → 1115
      DUF5401; Family of unknown function (DUF5401)

    3. XM_030243209.2 → XP_030099069.1  rho guanine nucleotide exchange factor 18 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPH6
      Conserved Domains (4) summary
      PRK13729
      Location:1153 → 1305
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:515 → 709
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:750 → 868
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1080 → 1197
      DUF5401; Family of unknown function (DUF5401)

    4. XM_030243211.2 → XP_030099071.1  rho guanine nucleotide exchange factor 18 isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPH6
      Conserved Domains (4) summary
      PRK13729
      Location:1071 → 1223
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:425 → 619
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:660 → 778
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:998 → 1115
      DUF5401; Family of unknown function (DUF5401)

    5. XM_006508682.4 → XP_006508745.1  rho guanine nucleotide exchange factor 18 isoform X4

      See identical proteins and their annotated locations for XP_006508745.1

      UniProtKB/TrEMBL
      A0A5F8MPF6
      Conserved Domains (4) summary
      PRK13729
      Location:748 → 900
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:675 → 775
      DUF5401; Family of unknown function (DUF5401)

    6. XM_036153699.1 → XP_036009592.1  rho guanine nucleotide exchange factor 18 isoform X5

      UniProtKB/TrEMBL
      A0A5F8MPF6
      Conserved Domains (4) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:667 → 783
      DUF5401; Family of unknown function (DUF5401)
      cl28929
      Location:740 → 892
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    7. XM_017312501.3 → XP_017167990.1  rho guanine nucleotide exchange factor 18 isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPF6
      Conserved Domains (4) summary
      PRK13729
      Location:748 → 900
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:675 → 775
      DUF5401; Family of unknown function (DUF5401)

    8. XM_036153700.1 → XP_036009593.1  rho guanine nucleotide exchange factor 18 isoform X5

      UniProtKB/TrEMBL
      A0A5F8MPF6
      Conserved Domains (4) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:667 → 783
      DUF5401; Family of unknown function (DUF5401)
      cl28929
      Location:740 → 892
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    9. XM_006508681.4 → XP_006508744.1  rho guanine nucleotide exchange factor 18 isoform X4

      See identical proteins and their annotated locations for XP_006508744.1

      UniProtKB/TrEMBL
      A0A5F8MPF6
      Conserved Domains (4) summary
      PRK13729
      Location:748 → 900
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:337 → 455
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:675 → 775
      DUF5401; Family of unknown function (DUF5401)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033378.3: Suppressed sequence

      Description
      NM_001033378.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9R4.3 GenPept UniProtKB/Swiss-Prot:Q6P9R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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