gcn5 SAGA complex histone acetyltransferase catalytic subunit Gcn5 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: gcn5
Official Full Name: SAGA complex histone acetyltransferase catalytic subunit Gcn5
Primary source: PomBase:SPAC1952.05
Locus tag: SPOM_SPAC1952.05
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: kat2
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Genomic context

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See gcn5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (4973624..4975698)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gcn5-mediated acetylation at MBF-regulated promoters induces the G1-S transcriptional wave.
Title: Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.
Our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.
Title: TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Data indicate that Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex contains a separable subcomplex known as the histone acetyltransferase (HAT) module that contains the HAT, Gcn5, bound to Sgf29.
Title: Nucleosome competition reveals processive acetylation by the SAGA HAT module.
Data indicate that the increase in leucine uptake in the gcn5Delta mutant was dependent on an amino acid permease gene, SPCC965.11c(+).
Title: The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.
Gcn5 mediates eviction of nucleosomes positioned downstream of promoters, allowing efficient Pol II progression along the genes.
Title: Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe.
Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation.
Title: HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress.
Data show that SAGA plays distinct roles in the control of the switch from proliferation to differentiation in S. pombe through the dynamic and opposing activities of Gcn5 and Spt8.
Title: The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
The histone acetyltransferase Gcn5 is required for most histone H3 acetylation around the meiotic recombination hotspot M26. Deletion of gcn5 causes a significant delay in chromatin remodeling but only partial reduction of M26 meiotic recomb. freq. [gcn5]
Title: Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K18 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone crotonyltransferase activity	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	EXP Inferred from Experiment more info	PubMed
enables transcription coactivator activity	IC Inferred by Curator more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of induction of conjugation with cellular fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of induction of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed
is_active_in pericentric heterochromatin	EXP Inferred from Experiment more info	PubMed

General protein information

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Preferred Names: SAGA complex histone acetyltransferase catalytic subunit Gcn5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

4973624..4975698

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001020236.3 → NP_594807.1 SAGA complex histone acetyltransferase catalytic subunit Gcn5 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_594807.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9UUK2

Conserved Domains (3) summary

cd05509
Location:347 → 446

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:95 → 454

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:170 → 245

Acetyltransf_1; Acetyltransferase (GNAT) family