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    slm9 histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540128, updated on 18-Sep-2024

    Summary

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    Official Symbol
    slm9
    Official Full Name
    histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2
    Primary source
    PomBase:SPBC15D4.03
    Locus tag
    SPOM_SPBC15D4.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    hip2
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    Genomic context

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    See slm9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3015532..3018155)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein gsf1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleotide-binding domain-containing protein CobW/HypB/UreG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast. Chujo M, et al. J Biol Chem, 2012 Jul 6. PMID 22589550, Free PMC Article
    2. The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts. Anderson HE, et al. Mol Cell Biol, 2009 Sep. PMID 19620282, Free PMC Article
    3. Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation. Greenall A, et al. J Biol Chem, 2006 Mar 31. PMID 16428807
    4. The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres. Blackwell C, et al. Mol Cell Biol, 2004 May. PMID 15121850, Free PMC Article
    5. ATAD2 controls chromatin-bound HIRA turnover. Wang T, et al. Life Sci Alliance, 2021 Dec. PMID 34580178, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that the fission yeast possesses two HIRA proteins Slm9 and Hip1.
      Title: HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.
    2. HIRA histone chaperone is required to maintain the protective functions of chromatin.
      Title: The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP-dependent H3-H4 histone complex chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    contributes_to H3-H4 histone complex chaperone activity IC
    Inferred by Curator
    more info
    		  
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HIR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3015532..3018155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022162.3 → NP_596243.1  histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596243.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74309
      Conserved Domains (4) summary
      COG2319
      Location:43 → 396
      WD40; WD40 repeat [General function prediction only]
      pfam07569
      Location:528 → 735
      Hira; TUP1-like enhancer of split
      sd00039
      Location:107 → 147
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:50 → 354
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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