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    pck1 protein kinase C (PKC)-like Pck1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pck1
    Official Full Name
    protein kinase C (PKC)-like Pck1
    Primary source
    PomBase:SPAC17G8.14c
    Locus tag
    SPOM_SPAC17G8.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC22H10.01c
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    Genomic context

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    See pck1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (2367140..2370612, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene exocyst complex subunit Sec3 Neighboring gene histone acetyltransferase Mst2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Ca(2+)-independent protein kinase C from fission yeast. Mazzei GJ, et al. J Biol Chem, 1993 Apr 5. PMID 8463273
    2. Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. Toda T, et al. EMBO J, 1993 May. PMID 8491190, Free PMC Article
    3. Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe. Gräub R, et al. J Basic Microbiol, 2003. PMID 14625898
    4. Rga5p is a specific Rho1p GTPase-activating protein that regulates cell integrity in Schizosaccharomyces pombe. Calonge TM, et al. Mol Microbiol, 2003 Jan. PMID 12519200
    5. The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Toda T, et al. Mol Cell Biol, 1996 Dec. PMID 8943330, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Constitutive Pck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell integrity pathway via Pck2.
      Title: Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.
    2. both Rho1 and Pck1 are positive upstream regulatory members of the CIP in addition to Rho2 and Pck2.
      Title: Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis, division site positioning EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C (PKC)-like Pck1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2367140..2370612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019168.3 → NP_593737.2  protein kinase C (PKC)-like Pck1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593737.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36582, Q9UTU9
      Conserved Domains (6) summary
      cd11621
      Location:2 → 73
      HR1_PKC-like_1_fungi; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins
      smart00220
      Location:664 → 923
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05570
      Location:668 → 983
      STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C
      pfam00130
      Location:481 → 533
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00087
      Location:111 → 180
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:212 → 316
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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