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    nrl1 NRDE-2 family protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540691, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nrl1
    Official Full Name
    NRDE-2 family protein
    Primary source
    PomBase:SPBC20F10.05
    Locus tag
    SPOM_SPBC20F10.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See nrl1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3290886..3294106)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene non-structural maintenance of chromosome element 4 Neighboring gene mitotic spindle checkpoint protein Mad2 Neighboring gene ncRNA Neighboring gene sterol transfer protein Ltc1 Neighboring gene RNA polymerase II nuclear import protein Rtp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation. Mikolaskova B, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209806, Free PMC Article
    2. Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing. Chalamcharla VR, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26631744, Free PMC Article
    3. The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Zhou Y, et al. Nat Commun, 2015 May 20. PMID 25989903, Free PMC Article
    4. The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Aronica L, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26682798, Free PMC Article
    5. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
      Title: Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
    2. we establish roles for the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regulation, R-loop suppression and in maintaining genome stability.
      Title: The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siRNA-mediated facultative heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    part_of spliceosomal complex EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NRDE-2 family protein
    NP_596369.1
    • RNAi-mediated silencing protein, human NRDE2 ortholog Nrl1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3290886..3294106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022290.3 → NP_596369.1  NRDE-2 family protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596369.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42975
      Conserved Domains (1) summary
      pfam08424
      Location:167 → 476
      NRDE-2; NRDE-2, necessary for RNA interference
    Nucleotide Protein
    Heading Accession and Version

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