ste11 DNA-binding transcription factor Ste11 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: ste11
Official Full Name: DNA-binding transcription factor Ste11
Primary source: PomBase:SPBC32C12.02
Locus tag: SPOM_SPBC32C12.02
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: aff1; stex
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Genomic context

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See ste11 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (3983376..3987400)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Therefore, ubiquitylated histone H2B represses gametogenesis by opposing the recruitment of RSC complex proteins at the promoter of the master regulator ste11 gene.
Title: Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus.
REVIEW: Regulation of entry into gametogenesis by Ste11
Title: Regulation of entry into gametogenesis by Ste11: the endless game.
Msa2 may regulate the translation of Ste11, be a component of stress granules that form in response to glucose starvation, and regulate the sexual differentiation of S. pombe.
Title: Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast.
Study conclude that both the PKA and the TOR pathways inhibit Ste11 nuclear accumulation to repress Ste11-dependent gene expression.
Title: TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
Data show that the SAGA subunit Spt8 is required for the induction of ste11(+) upon nutrient starvation. and SAGA is physically associated with the ste11(+) promoter independent of nutrient levels.
Title: The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Ste11 transcription factor becomes constitutively expressed in cells with induced mitogen-activated protein kinase kinase kinase (MAP3K) Byr2.
Title: Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.
In fission yeast, induction of the transcription factor Ste11 triggers sexual differentiation.
Title: Cdk phosphorylation of the Ste11 transcription factor constrains differentiation-specific transcription to G1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	EXP Inferred from Experiment more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in induction of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of induction of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Tor2-Mei2-Ste11 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in nucleoplasm	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding transcription factor Ste11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

3983376..3987400

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022578.3 → NP_596656.1 DNA-binding transcription factor Ste11 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_596656.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O59696, P36631, Q9UU71

Conserved Domains (1) summary

cd01389
Location:16 → 87

MATA_HMG-box; MATA_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include the fungal mating type gene products MC, ...