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    tfs1 general transcription elongation factor TFIIS [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541941, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tfs1
    Official Full Name
    general transcription elongation factor TFIIS
    Primary source
    PomBase:SPAC20H4.03c
    Locus tag
    SPOM_SPAC20H4.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tfs1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (2114913..2116456, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bromodomain-containing protein Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp5 Neighboring gene protein dsc3 Neighboring gene ATP-dependent 3'-5'-directionality DNA helicase fml2 Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene ncRNA Neighboring gene Gpl1-Gih35-Wdr83 complex RNA-binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tfs1, transcription elongation factor TFIIS, has an impact on chromosome segregation affected by pka1 deletion in Schizosaccharomyces pombe. Takenaka K, et al. Curr Genet, 2023 Jun. PMID 37052630
    2. The Rpb6 subunit of fission yeast RNA polymerase II is a contact target of the transcription elongation factor TFIIS. Ishiguro A, et al. Mol Cell Biol, 2000 Feb. PMID 10648612, Free PMC Article
    3. The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Lemay JF, et al. Nat Struct Mol Biol, 2014 Oct. PMID 25240800
    4. Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin. Reyes-Turcu FE, et al. Nat Struct Mol Biol, 2011 Sep 4. PMID 21892171, Free PMC Article
    5. Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast. Koike A, et al. J Biol Chem, 2012 Jun 1. PMID 22496451, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription elongation factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    general transcription elongation factor TFIIS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2114913..2116456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019054.3 → NP_593623.1  general transcription elongation factor TFIIS [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593623.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P49373
      Conserved Domains (4) summary
      cd00183
      Location:3 → 78
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:246 → 292
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:3 → 293
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:131 → 237
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
    Nucleotide Protein
    Heading Accession and Version

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