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    frp1 Fe(3+)-chelate reductase Frp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539711, updated on 18-Sep-2024

    Summary

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    Official Symbol
    frp1
    Official Full Name
    Fe(3+)-chelate reductase Frp1
    Primary source
    PomBase:SPBC1683.09c
    Locus tag
    SPOM_SPBC1683.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See frp1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (160357..162392, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hexose transporter Ght4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe(2+) transporter Pcl1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase. Roman DG, et al. Mol Cell Biol, 1993 Jul. PMID 8321236, Free PMC Article
    2. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ferric-chelate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables iron ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reductive iron assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reductive iron assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fe(3+)-chelate reductase Frp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      160357..162392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020971.3 → NP_595065.1  Fe(3+)-chelate reductase Frp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595065.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q04800
      Conserved Domains (3) summary
      cd06186
      Location:279 → 480
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:124 → 235
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:414 → 547
      NAD_binding_6; Ferric reductase NAD binding domain
    Nucleotide Protein
    Heading Accession and Version

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