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    nep1 NEDD8 protease Nep1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539808, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nep1
    Official Full Name
    NEDD8 protease Nep1
    Primary source
    PomBase:SPBC17D11.01
    Locus tag
    SPOM_SPBC17D11.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See nep1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3304535..3306572)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pho85 family cyclin Neighboring gene ncRNA Neighboring gene synviolin family ubiquitin-protein ligase Hrd1 Neighboring gene ncRNA Neighboring gene carboxymuconolactone decarboxylase-like protein, Pxp2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nedd8 processing enzymes in Schizosaccharomyces pombe. O'Donoghue JE, et al. BMC Biochem, 2013 Mar 15. PMID 23496905, Free PMC Article
    2. Nep1, a Schizosaccharomyces pombe deneddylating enzyme. Zhou L, et al. Biochem J, 2005 Jul 15. PMID 15769255, Free PMC Article
    3. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
    4. Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. Navarro FJ, et al. J Cell Sci, 2017 Dec 15. PMID 29084823, Free PMC Article
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deNEDDylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deNEDDylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8 protease Nep1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3304535..3306572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022296.3 → NP_596375.2  NEDD8 protease Nep1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596375.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42980, P78807
      Conserved Domains (1) summary
      cl23802
      Location:27 → 217
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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