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    vps4 AAA family ATPase Vps4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542054, updated on 18-Sep-2024

    Summary

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    Official Symbol
    vps4
    Official Full Name
    AAA family ATPase Vps4
    Primary source
    PomBase:SPAC2G11.06
    Locus tag
    SPOM_SPAC2G11.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See vps4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (818003..819739)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BRO1 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein phosphatase PP2C catalytic subunit Ptc3 Neighboring gene ncRNA Neighboring gene SMN complex subunit Smn1/Gem1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast. Rezig IM, et al. Cell Cycle, 2021 Sep. PMID 34382912, Free PMC Article
    2. A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe. Bhutta MS, et al. PLoS One, 2014. PMID 25356547, Free PMC Article
    3. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Gu M, et al. Proc Natl Acad Sci U S A, 2017 Mar 14. PMID 28242692, Free PMC Article
    4. Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. Iwaki T, et al. Microbiology (Reading), 2007 Aug. PMID 17660439, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear membrane reassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    AAA family ATPase Vps4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      818003..819739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018484.3 → NP_593086.1  AAA family ATPase Vps4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593086.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09803
      Conserved Domains (5) summary
      cd02678
      Location:5 → 79
      MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
      PTZ00454
      Location:7 → 387
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:165 → 294
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:370 → 429
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:130 → 184
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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