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    cpp1 protein farnesyltransferase beta subunit Cpp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542380, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cpp1
    Official Full Name
    protein farnesyltransferase beta subunit Cpp1
    Primary source
    PomBase:SPAC17G6.04c
    Locus tag
    SPOM_SPAC17G6.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cpp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3592994..3596406, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene phosphoprotein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar protein-sorting protein Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis. Imagawa K, et al. Kobe J Med Sci, 2009 Jun 5. PMID 20847589
    2. Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase. Murai T, et al. Genetics, 2009 Oct. PMID 19620394, Free PMC Article
    3. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. Yang W, et al. J Biol Chem, 2000 Jan 7. PMID 10617635
    4. Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast. Ma Y, et al. Mol Biol Cell, 2006 Dec. PMID 17005909, Free PMC Article
    5. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Nakase Y, et al. Genetics, 2006 Jun. PMID 16624901, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that Cpp1 is a key component of the Pck2-Pmk1 signaling through the spatial control of the small GTPase Rho2.
      Title: Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to protein farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein farnesyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein farnesyltransferase beta subunit Cpp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3592994..3596406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019674.3 → NP_594251.1  protein farnesyltransferase beta subunit Cpp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13782
      Conserved Domains (2) summary
      COG5029
      Location:4 → 376
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
      cd02893
      Location:32 → 327
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    Nucleotide Protein
    Heading Accession and Version

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