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    rgf1 RhoGEF family guanine nucleotide exchange factor Rgf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539580, updated on 14-Nov-2024

    Summary

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    Official Symbol
    rgf1
    Official Full Name
    RhoGEF family guanine nucleotide exchange factor Rgf1
    Primary source
    PomBase:SPCC645.07
    Locus tag
    SPOM_SPCC645.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rgf1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1245186..1249470)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RhoGEF for Rho1, Rgf3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tudor domain and nuclease, Snd1 Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival. Davì V, et al. Dev Cell, 2018 Apr 23. PMID 29689193
    2. Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p. García P, et al. Genetics, 2009 Apr. PMID 19189958, Free PMC Article
    3. The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast. Garcia P, et al. Mol Biol Cell, 2009 Jan. PMID 19037094, Free PMC Article
    4. Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner. Onwubiko UN, et al. J Cell Sci, 2023 Apr 15. PMID 37039135, Free PMC Article
    5. Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast. Mutoh T, et al. Genes Cells, 2005 Dec. PMID 16324155

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rgf1p and Rgf2p are alternative guanine nucleotide exchange factors with an essential overlapping function in Rho1p activation during vegetative growth.
      Title: Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p.
    2. Results show that Rgf1p, a Rho1p-specific GEF, acts upstream from the Pck2-Pmk1p MAPK cell integrity signaling pathway.
      Title: The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.
    3. Rgf1p probably activates the Rho1 functions necessary for coordinating actin deposition with cell wall biosynthesis during bipolar growth, allowing the cells to remodel their wall without risk of rupture.
      Title: Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.
    4. Rgf1 is involved in cell wall and septum formation.
      Title: Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell growth mode switching, monopolar to bipolar IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell wall organization or biogenesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell wall organization or biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of non-growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RhoGEF family guanine nucleotide exchange factor Rgf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1245186..1249470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023106.3 → NP_588116.1  RhoGEF family guanine nucleotide exchange factor Rgf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588116.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y7U6
      Conserved Domains (5) summary
      COG5422
      Location:6 → 1320
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      cd04435
      Location:416 → 497
      DEP_fRom2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) Rom2-like proteins. Rom2-like proteins share a common domain architecture, containing, beside the RhoGEF domain, a DEP, a PH (pleckstrin homology) and a CNH ...
      pfam00621
      Location:625 → 806
      RhoGEF; RhoGEF domain
      pfam00780
      Location:1004 → 1290
      CNH; CNH domain
      pfam15405
      Location:844 → 972
      PH_5; Pleckstrin homology domain
    Nucleotide Protein
    Heading Accession and Version

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