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    srw1 substrate-specific mitotic G1 APC coactivator Srw1/Ste9 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542824, updated on 18-Sep-2024

    Summary

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    Official Symbol
    srw1
    Official Full Name
    substrate-specific mitotic G1 APC coactivator Srw1/Ste9
    Primary source
    PomBase:SPAC144.13c
    Locus tag
    SPOM_SPAC144.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ste9
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    Genomic context

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    See srw1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4677611..4680193, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS17 Neighboring gene ribose 5-phosphate isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene kinesin-like protein Klp8 Neighboring gene COG complex subunit Cog1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast APC activator Ste9 is regulated by mRNA decay. Alvarez B, et al. Cell Cycle, 2006 Apr. PMID 16627999
    2. Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation. Yamaguchi S, et al. EMBO J, 2000 Aug 1. PMID 10921878, Free PMC Article
    3. A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Chu Z, et al. Mol Cell Biol, 2009 Sep. PMID 19596787, Free PMC Article
    4. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco MA, et al. EMBO J, 2000 Aug 1. PMID 10921876, Free PMC Article
    5. Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast. Trickey M, et al. J Biol Chem, 2013 Jan 11. PMID 23195958, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest.
      Title: A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.
    2. Ste9 is regulated by mRNA decay
      Title: The fission yeast APC activator Ste9 is regulated by mRNA decay.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin ligase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G1 cell size control checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic G1 cell size control checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    substrate-specific mitotic G1 APC coactivator Srw1/Ste9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4677611..4680193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020103.3 → NP_594674.1  substrate-specific mitotic G1 APC coactivator Srw1/Ste9 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594674.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A7VJ97, O13286
      Conserved Domains (3) summary
      COG2319
      Location:272 → 536
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:291 → 532
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:295 → 331
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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