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    zfs1 zinc finger protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539958, updated on 18-Sep-2024

    Summary

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    Official Symbol
    zfs1
    Official Full Name
    zinc finger protein
    Primary source
    PomBase:SPBC1718.07c
    Locus tag
    SPOM_SPBC1718.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    moc4
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    Genomic context

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    See zfs1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3482848..3487446, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glycerol-3-phosphate O-acyltransferase Neighboring gene TRAPP complex subunit Trs31 Neighboring gene dynamin family GTPase Msp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe. Cuthbertson BJ, et al. J Biol Chem, 2008 Feb 1. PMID 18042546, Free PMC Article
    2. Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway. Kanoh J, et al. Mol Biol Cell, 1995 Sep. PMID 8534915, Free PMC Article
    3. Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe. Goldar MM, et al. Curr Genet, 2005 Dec. PMID 16273369
    4. The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity. Hakuno F, et al. Genes Cells, 1996 Mar. PMID 9133664
    5. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Nakase Y, et al. Genetics, 2006 Jun. PMID 16624901, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We also found that Zfs1 undergoes phosphorylation, which is stimulated upon nitrogen depletion or inhibition of the TOR pathway. Phosphorylation of Zfs1 modulates accumulation of Puc1 and plays an important role in the response of the cell to sexual differentiation signals.
      Title: Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
    2. The data suggested that Zfs1p can both directly and indirectly regulate the levels of transcripts involved in cell-cell adhesion.
      Title: Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
    3. zfs1 and its targets represent a useful model system for studies of zinc finger protein/AU-rich element interactions that result in mRNA decay.
      Title: Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exoribonuclease activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pumilio-response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle switching, mitotic to meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein
    NP_596453.1
    • zf-CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3482848..3487446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022372.3 → NP_596453.1  zinc finger protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596453.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P47979
      Conserved Domains (2) summary
      COG5063
      Location:8 → 404
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam00642
      Location:327 → 352
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    Nucleotide Protein
    Heading Accession and Version

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