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    eri1 double-strand siRNA ribonuclease Eri1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540347, updated on 3-Dec-2024

    Summary

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    Official Symbol
    eri1
    Official Full Name
    double-strand siRNA ribonuclease Eri1
    Primary source
    PomBase:SPBC30B4.08
    Locus tag
    SPOM_SPBC30B4.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See eri1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (1320720..1323215)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GIDA family tRNA uridine 5-carboxymethylaminomethyl modification enzyme Neighboring gene ncRNA Neighboring gene transcription factor TFIIH complex subunit Tfb4 Neighboring gene ERMES complex subunit Mmm1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Mis19 Neighboring gene C-5 sterol desaturase Erg32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Gabel HW, et al. Nat Struct Mol Biol, 2008 May. PMID 18438419, Free PMC Article
    2. Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast. Iida T, et al. Curr Biol, 2006 Jul 25. PMID 16797182
    3. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe.
      Title: The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of regulatory ncRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    double-strand siRNA ribonuclease Eri1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1320720..1323215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356215.2 → NP_001343023.2  double-strand siRNA ribonuclease Eri1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13668, Q08I43
      UniProtKB/TrEMBL
      A0AAN2L411
    Nucleotide Protein
    Heading Accession and Version

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