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    nuc2 anaphase-promoting complex TPR lobe subcomplex subunit Apc3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542438, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nuc2
    Official Full Name
    anaphase-promoting complex TPR lobe subcomplex subunit Apc3
    Primary source
    PomBase:SPAC17C9.01c
    Locus tag
    SPOM_SPAC17C9.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    apc3; SPAC1851.01
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    Genomic context

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    See nuc2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4498096..4500581)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-aminoadipate reductase phosphopantetheinyl transferase Lys7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase Slc1 Neighboring gene CK2 family regulatory subunit Ckb1 Neighboring gene Rab-specific(Ryh1/Ypt6) Ric1-Rgp1 guanyl-nucleotide exchange factor subunit Ric1/Sat4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+. Hirano T, et al. Cell, 1990 Jan 26. PMID 2297790
    2. Gene products required for chromosome separation. Yanagida M. J Cell Sci Suppl, 1989. PMID 2561424
    3. A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. Hirano T, et al. J Cell Biol, 1988 Apr. PMID 3283148, Free PMC Article
    4. Fission yeast TPR-family protein nuc2 is required for G1-arrest upon nitrogen starvation and is an inhibitor of septum formation. Kumada K, et al. J Cell Sci, 1995 Mar. PMID 7622618
    5. [Overexpression of the apc10+ gene in the fission yeast Schizosaccharomyces pombe can suppress temperature sensitivity of the nuc2-663 mutant,but not its sterility]. Grishchuk EL, et al. Mol Biol (Mosk), 2000 Sep-Oct. PMID 11033806

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuc2p, by inhibiting the septation initiation network after cell division, prevents further deleterious cytokinetic events, thereby contributing to genome stability.
      Title: Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle switching, mitotic to meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid separation IC
    Inferred by Curator
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex TPR lobe subcomplex subunit Apc3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4498096..4500581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020032.3 → NP_594604.2  anaphase-promoting complex TPR lobe subcomplex subunit Apc3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594604.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P10505, Q9US21
      Conserved Domains (6) summary
      COG0457
      Location:376 → 652
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:466 → 493
      TPR; TPR repeat [structural motif]
      cd15832
      Location:463 → 512
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:499 → 532
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:14 → 91
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      cl24038
      Location:438 → 597
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    Nucleotide Protein
    Heading Accession and Version

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