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    tgs1 RNA methyltransferase Tgs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542015, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tgs1
    Official Full Name
    RNA methyltransferase Tgs1
    Primary source
    PomBase:SPAC2G11.15c
    Locus tag
    SPOM_SPAC2G11.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC521.01c; tgs2
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    Genomic context

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    See tgs1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (841471..842625, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar amino acid transmembrane transporter Atg22 Neighboring gene transcription factor TFIID complex, histone acetyltransferase subunit Taf111 Neighboring gene ncRNA Neighboring gene dehydrogenase Neighboring gene DNA repair WLM domain metallopeptidase Wss1 Neighboring gene calcium permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Hausmann S, et al. Nucleic Acids Res, 2007. PMID 17284461, Free PMC Article
    2. Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). Hausmann S, et al. J Biol Chem, 2005 Feb 11. PMID 15590684
    3. The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence. Deng X, et al. Nucleic Acids Res, 2024 Aug 27. PMID 38828770, Free PMC Article
    4. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article
    5. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapping the Tgs2 active site by mutagenesis.
      Title: Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.
    2. The methyltransferase Tgs1, a catalyst of TMG cap synthesis, is guanine-specific; N7 methylation must precede N2 methylation; it acts via a distributive mechanism; and the chemical steps of TMG synthesis do not require RNA or protein cofactors. [Tgs1]
      Title: Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA cap trimethylguanosine synthase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA cap trimethylguanosine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap trimethylguanosine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 7-methylguanosine cap hypermethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine cap hypermethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle HDA PubMed 
    is_active_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA methyltransferase Tgs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      841471..842625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018493.4 → NP_593095.3  RNA methyltransferase Tgs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593095.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78826, Q09814, Q9P7B6
      Conserved Domains (1) summary
      pfam09445
      Location:74 → 232
      Methyltransf_15; RNA cap guanine-N2 methyltransferase
    Nucleotide Protein
    Heading Accession and Version

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