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    tup11 transcriptional corepressor Tup11 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542299, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tup11
    Official Full Name
    transcriptional corepressor Tup11
    Primary source
    PomBase:SPAC18B11.10
    Locus tag
    SPOM_SPAC18B11.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tup11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (299278..301796, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine O-acetyltransferase activity Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins. Ferreira ME, et al. PLoS One, 2010 Jun 8. PMID 20544037, Free PMC Article
    2. Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog. Mukai Y, et al. Mol Cell Biol, 1999 Dec. PMID 10567571, Free PMC Article
    3. Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. Pelletier B, et al. J Biol Chem, 2005 Jul 1. PMID 15866870
    4. Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling. Hirota K, et al. Eukaryot Cell, 2006 Dec. PMID 17028240, Free PMC Article
    5. Expression of Candida albicans Sfu1 in fission yeast complements the loss of the iron-regulatory transcription factor Fep1 and requires Tup co-repressors. Pelletier B, et al. Yeast, 2007 Oct. PMID 17724773

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tup11 and Tup12 proteins in fission yeasts thus provide an excellent model system for studying the functional divergence of WD40 repeat domains
      Title: WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.
    2. The LAMMER kinase homolog, Lkh1, regulates Tup11,12 transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.
      Title: The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.
    3. Ssn6, Tup11, and Tup12 are preferentially found at genomic locations at which histones are deacetylated, primarily by the Clr6 class I histone deacetylases.
      Title: Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.
    4. Tup11 and Tup12 persist in the nucleus and bind to the fbp1+ promoter under both derepressed and repressed conditions
      Title: Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling.
    5. The transcriptional corepressors Tup11 and Tup12 have retained the ability to interact with the Ssn6 protein and with each other, but they also have some distinct functions. Tup12 has evolved a specialized role in stress response regulation. [Tup11]
      Title: Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cyc8(Ssn6)-Tup1 general repressor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    transcriptional corepressor Tup11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      299278..301796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018273.3 → NP_592873.1  transcriptional corepressor Tup11 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592873.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09715, Q9USG3
      Conserved Domains (4) summary
      COG2319
      Location:303 → 610
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:306 → 608
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08581
      Location:9 → 86
      Tup_N; Tup N-terminal
      sd00039
      Location:316 → 358
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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