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    dpb2 DNA polymerase epsilon catalytic subunit B Dpb2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541347, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dpb2
    Official Full Name
    DNA polymerase epsilon catalytic subunit B Dpb2
    Primary source
    PomBase:SPBP8B7.14c
    Locus tag
    SPOM_SPBP8B7.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dpb2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3656748..3658930, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CENP-H-like protein Fta3 Neighboring gene ncRNA Neighboring gene protein vac7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RBBP6 family ubiquitin-protein ligase E3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication. Feng W, et al. Mol Biol Cell, 2003 Aug. PMID 12925774, Free PMC Article
    2. Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast. Spiga MG, et al. Nucleic Acids Res, 2004. PMID 15388803, Free PMC Article
    3. Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Taricani L, et al. Mol Biol Cell, 2006 Aug. PMID 16723501, Free PMC Article
    4. Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. Yabuuchi H, et al. EMBO J, 2006 Oct 4. PMID 16990792, Free PMC Article
    5. Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. Kanke M, et al. EMBO J, 2012 May 2. PMID 22433840, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc20 and Dpb2 of the Pol epsilon complex are required for loading of GINS, Cut5, Drc1, and Cdc45 onto replication origins.
      Title: DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMG complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in mitotic DNA replication IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IC
    Inferred by Curator
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA polymerase epsilon catalytic subunit B Dpb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3656748..3658930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022442.3 → NP_596521.1  DNA polymerase epsilon catalytic subunit B Dpb2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596521.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94263
      Conserved Domains (1) summary
      pfam04042
      Location:333 → 556
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    Nucleotide Protein
    Heading Accession and Version

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