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    gea1 guanyl-nucleotide exchange factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540746, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gea1
    Official Full Name
    guanyl-nucleotide exchange factor
    Primary source
    PomBase:SPBC211.03c
    Locus tag
    SPOM_SPBC211.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gea1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3875125..3879920, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene protein Cwf3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MCM complex subunit Mcm6 Neighboring gene ncRNA Neighboring gene splicing factor 3B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast. Eckler AM, et al. PLoS One, 2013. PMID 23457617, Free PMC Article
    2. Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast. Ikebe C, et al. Biosci Biotechnol Biochem, 2011. PMID 22146723
    3. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gea1 in regulation of septum breakdown and establish S. pombe as a model system to explore GBF1/GEA function in cytokinesis
      Title: Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    guanyl-nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3875125..3879920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022534.3 → NP_596613.1  guanyl-nucleotide exchange factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596613.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7R8
      Conserved Domains (3) summary
      COG5307
      Location:289 → 1303
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:548 → 732
      Sec7; Sec7 domain
      pfam12783
      Location:287 → 475
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    Nucleotide Protein
    Heading Accession and Version

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