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    peg1 CLASP family microtubule-associated protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543399, updated on 18-Sep-2024

    Summary

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    Official Symbol
    peg1
    Official Full Name
    CLASP family microtubule-associated protein
    Primary source
    PomBase:SPAC3G9.12
    Locus tag
    SPOM_SPAC3G9.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cls1
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    Genomic context

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    See peg1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3152026..3157332, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tryptophan--tRNA (Trp) ligase Msw1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe. Chiron S, et al. J Cell Biol, 2008 Jul 14. PMID 18606849, Free PMC Article
    2. Stabilization of overlapping microtubules by fission yeast CLASP. Bratman SV, et al. Dev Cell, 2007 Dec. PMID 18061564, Free PMC Article
    3. CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Al-Bassam J, et al. Dev Cell, 2010 Aug 17. PMID 20708587, Free PMC Article
    4. CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast. Ebina H, et al. Biol Open, 2019 Oct 24. PMID 31615768, Free PMC Article
    5. PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation. Kelkar M, et al. Nat Commun, 2015 Oct 7. PMID 26443240, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKA signalling tunes CLASP's activity to promote Pom1 cell side localization and buffer cell size upon glucose starvation.
      Title: PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
    2. Results propose a mechanism for microtubule (MT) rescue in which CLASP-tubulin dimer complexes bind along the MT lattice and reverse MT depolymerization with their bound tubulin dimer.
      Title: CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.
    3. Peg1p is the first identified microtubule plus end-binding protein required for mitochondrial distribution and likely functions as a molecular link between mitochondria and microtubules.
      Title: CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe.
    4. S. pombe CLASP influences microtubule dynamics in different ways in different cell cycle stages.
      Title: S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in astral microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule bundle maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle formation (spindle phase one) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic microtubule minus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    NOT is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton HDA PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in static microtubule bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLASP family microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3152026..3157332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019501.3 → NP_594084.1  CLASP family microtubule-associated protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594084.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42874
      Conserved Domains (1) summary
      pfam12348
      Location:273 → 499
      CLASP_N; CLASP N terminal
    Nucleotide Protein
    Heading Accession and Version

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