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    fas2 fatty acid synthase alpha subunit Fas2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543618, updated on 14-Nov-2024

    Summary

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    Official Symbol
    fas2
    Official Full Name
    fatty acid synthase alpha subunit Fas2
    Primary source
    PomBase:SPAC4A8.11c
    Locus tag
    SPOM_SPAC4A8.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    lsd1
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    Genomic context

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    See fas2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2566866..2572618, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Cwf21 Neighboring gene lipase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP1 regulatory subunit Sds22 Neighboring gene 20S proteasome complex subunit beta 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1. Yokoyama K, et al. Biochim Biophys Acta, 2001 Jun 29. PMID 11470243
    2. Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. Saitoh S, et al. J Cell Biol, 1996 Aug. PMID 8769419, Free PMC Article
    3. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Lan F, et al. Mol Cell, 2007 Apr 13. PMID 17434129
    4. Cloning of the fatty acid synthetase beta subunit from fission yeast, coexpression with the alpha subunit, and purification of the intact multifunctional enzyme complex. Niwa H, et al. Protein Expr Purif, 1998 Aug. PMID 9693066
    5. Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe. Selicky T, et al. Int J Mol Sci, 2022 Oct 24. PMID 36361590, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to fatty-acyl-CoA synthase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables holo-[acyl-carrier-protein] synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in palmitic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of fatty acid synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid synthase alpha subunit Fas2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2566866..2572618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019252.3 → NP_593823.1  fatty acid synthase alpha subunit Fas2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593823.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14163, P78866, P78973, Q10289, Q96WT6, Q96WT7, Q96WT8, Q9URI5
      Conserved Domains (6) summary
      cd08950
      Location:629 → 888
      KR_fFAS_SDR_c_like; ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs
      COG0331
      Location:21 → 86
      FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
      COG4982
      Location:95 → 1126
      FabG2; 3-oxoacyl-ACP reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
      cd00828
      Location:1094 → 1614
      elong_cond_enzymes; "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as ...
      PTZ00050
      Location:1137 → 1606
      PTZ00050; 3-oxoacyl-acyl carrier protein synthase; Provisional
      TIGR00556
      Location:1721 → 1842
      pantethn_trn; phosphopantetheine--protein transferase domain
    Nucleotide Protein
    Heading Accession and Version

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