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    dph3 diphthamide biosynthesis protein Dph3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543434, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dph3
    Official Full Name
    diphthamide biosynthesis protein Dph3
    Primary source
    PomBase:SPAC8F11.02c
    Locus tag
    SPOM_SPAC8F11.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dph3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (2854405..2855694, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein Ltv1 Neighboring gene 60S ribosomal protein eL41 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA mismatch repair protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents. Villahermosa D, et al. Curr Genet, 2017 Dec. PMID 28555368, Free PMC Article
    2. Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNA(Lys)(UUU) modifications. Villahermosa D, et al. Sci Rep, 2017 Aug 3. PMID 28775286, Free PMC Article
    3. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038
    4. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.
      Title: A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    diphthamide biosynthesis protein Dph3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2854405..2855694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356085.2 → NP_001342897.1  diphthamide biosynthesis protein Dph3 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT33
      Conserved Domains (1) summary
      COG5216
      Location:1 → 67
      COG5216; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version

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