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    dfp1 Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539399, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dfp1
    Official Full Name
    Hsk1-Dfp1 kinase complex regulatory subunit Dfp1
    Primary source
    PomBase:SPCC550.13
    Locus tag
    SPOM_SPCC550.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    dbf4; him1; rad35
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    Genomic context

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    See dfp1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1214326..1216438)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Swr1 actin-like protein Arp6 Neighboring gene ncRNA Neighboring gene vigilin Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in Schizosaccharomyces pombe. Shen KF, et al. Genetics, 2019 Jun. PMID 31000521, Free PMC Article
    2. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Brown GW, et al. Proc Natl Acad Sci U S A, 1999 Jul 20. PMID 10411894, Free PMC Article
    3. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. Ogino K, et al. J Biol Chem, 2001 Aug 17. PMID 11402029
    4. A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase. Fung AD, et al. Mol Cell Biol, 2002 Jul. PMID 12052858, Free PMC Article
    5. The Hsk1(Cdc7) replication kinase regulates origin efficiency. Patel PK, et al. Mol Biol Cell, 2008 Dec. PMID 18799612, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swi6 interacts with Dfp1, a regulatory subunit of DBF4-dependent kinase (DDK), and failure to recruit Dfp1 to the pericentromere results in late DNA replication.
      Title: Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in Schizosaccharomyces pombe.
    2. Hsk1-Dfp1/Him1 and Swi1-Swi3 complexes have interrelated roles in stabilization of arrested replication forks
      Title: Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear cell cycle DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Dbf4-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dbf4-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Dbf4-dependent protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hsk1-Dfp1 kinase complex regulatory subunit Dfp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1214326..1216438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023096.3 → NP_588105.1  Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588105.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59836
      Conserved Domains (4) summary
      smart00586
      Location:492 → 540
      ZnF_DBF; Zinc finger in DBF-like proteins
      COG5067
      Location:10 → 542
      DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
      cd00027
      Location:152 → 222
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam08630
      Location:206 → 324
      Dfp1_Him1_M; Dfp1/Him1, central region
    Nucleotide Protein
    Heading Accession and Version

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