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    spt8 SAGA complex subunit Spt8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539775, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spt8
    Official Full Name
    SAGA complex subunit Spt8
    Primary source
    PomBase:SPBC14C8.17c
    Locus tag
    SPOM_SPBC14C8.17C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sep9
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    Genomic context

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    See spt8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2233461..2235778, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene triglyceride lipase-cholesterol esterase Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein subunit S45 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TPR repeat-containing protein Oca3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage. Batta G, et al. FEMS Yeast Res, 2009 Aug. PMID 19473263
    2. Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation. Grallert A, et al. Yeast, 1999 Jun 15. PMID 10392445
    3. The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast. Takahashi H, et al. J Biol Chem, 2012 Nov 2. PMID 22992726, Free PMC Article
    4. Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. Elmore ZC, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948786, Free PMC Article
    5. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. Bao K, et al. Genes Dev, 2019 Jan 1. PMID 30573453, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that SAGA plays distinct roles in the control of the switch from proliferation to differentiation in S. pombe through the dynamic and opposing activities of Gcn5 and Spt8.
      Title: The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    SAGA complex subunit Spt8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2233461..2235778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021828.3 → NP_595920.1  SAGA complex subunit Spt8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595920.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60097
      Conserved Domains (4) summary
      COG2319
      Location:120 → 473
      WD40; WD40 repeat [General function prediction only]
      pfam05285
      Location:35 → 95
      SDA1; SDA1
      sd00039
      Location:121 → 161
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:120 → 469
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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