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    grx5 mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543483, updated on 14-Nov-2024

    Summary

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    Official Symbol
    grx5
    Official Full Name
    mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5
    Primary source
    PomBase:SPAPB2B4.02
    Locus tag
    SPOM_SPAPB2B4.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See grx5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2708048..2709309)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pig-L family GPI synthesis protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G1/S-specific B-type cyclin Cig2 Neighboring gene P2 type calcium transporting P-type ATPase Pmc1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast gene encoding monothiol glutaredoxin 5 is regulated by nitrosative and osmotic stresses. Kim HG, et al. Mol Cells, 2005 Aug 31. PMID 16258240
    2. Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe. Chung WH, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796926
    3. Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Brancaccio D, et al. J Am Chem Soc, 2014 Nov 19. PMID 25347204
    4. The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation. Uzarska MA, et al. Mol Biol Cell, 2013 Jun. PMID 23615440, Free PMC Article
    5. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2.
      Title: Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione disulfide oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in [2Fe-2S] cluster assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in [4Fe-4S] cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2708048..2709309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019318.3 → NP_593888.1  mitochondrial [2Fe-2S] cluster assembly and transfer glutaredoxin Grx5 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HDW8
      Conserved Domains (1) summary
      COG0278
      Location:22 → 128
      GrxD; Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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