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    pnk1 DNA kinase/phosphatase Pnk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542032, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pnk1
    Official Full Name
    DNA kinase/phosphatase Pnk1
    Primary source
    PomBase:SPAC23C11.04c
    Locus tag
    SPOM_SPAC23C11.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pnk1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (2136034..2139467, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene family protein ICE2 Neighboring gene 40S ribosomal protein uS12 Neighboring gene U3 snoRNP-associated protein Mpp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hydrolase Neighboring gene ncRNA Neighboring gene inorganic pyrophosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. Meijer M, et al. J Biol Chem, 2002 Feb 8. PMID 11729194
    2. Purification and partial characterization of a DNA 3'-phosphatase from Schizosaccharomyces pombe. Jilani A, et al. Biochemistry, 2002 Jun 18. PMID 12056900
    3. Polynucleotide kinase/phosphatase, Pnk1, is involved in base excision repair in Schizosaccharomyces pombe. Kashkina E, et al. DNA Repair (Amst), 2012 Aug 1. PMID 22748672
    4. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. Ganguly A, et al. PLoS Genet, 2018 Aug. PMID 30148840, Free PMC Article
    5. Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast. Sanchez A, et al. PLoS Genet, 2017 Sep. PMID 28922417, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polynucleotide 3'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polynucleotide 3'-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polynucleotide 3'-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single strand break repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA kinase/phosphatase Pnk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2136034..2139467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019066.3 → NP_593635.2  DNA kinase/phosphatase Pnk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593635.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13911
      Conserved Domains (4) summary
      cd01427
      Location:71 → 212
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      pfam08645
      Location:70 → 220
      PNK3P; Polynucleotide kinase 3 phosphatase
      pfam13671
      Location:258 → 379
      AAA_33; AAA domain
      cl17190
      Location:258 → 366
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version

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