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    rtf2 DNA replication termination factor Rtf2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542468, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rtf2
    Official Full Name
    DNA replication termination factor Rtf2
    Primary source
    PomBase:SPAC1D4.09c
    Locus tag
    SPOM_SPAC1D4.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rtf2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (652225..653272, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cyclin-dependent kinase-activating kinase Csk1 Neighboring gene ncRNA Neighboring gene phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1 Neighboring gene ncRNA Neighboring gene 3' tRNA-processing endonuclease tRNAse Z L2 Trz1 Neighboring gene ncRNA Neighboring gene dual-specificity

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1. Budden AM, et al. Elife, 2023 Aug 24. PMID 37615341, Free PMC Article
    2. Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart. Inagawa T, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416828, Free PMC Article
    3. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rtf2 stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin
      Title: Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT involved_in replication fork arrest EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT involved_in replication fork processing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in replication fork EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of spliceosomal complex EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication termination factor Rtf2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      652225..653272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018421.3 → NP_593022.1  DNA replication termination factor Rtf2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593022.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10154
      UniProtKB/TrEMBL
      C1M2W1
      Conserved Domains (1) summary
      pfam04641
      Location:1 → 239
      Rtf2; Rtf2 RING-finger
    Nucleotide Protein
    Heading Accession and Version

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