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    Rab11b RAB11B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79434, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab11bprovided by RGD
    Official Full Name
    RAB11B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:68369
    See related
    EnsemblRapid:ENSRNOG00000007648 AllianceGenome:RGD:68369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in constitutive secretory pathway; regulated exocytosis; and regulation of presynaptic dense core granule exocytosis. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human RAB11B (RAB11B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 191.1), Brain (RPKM 169.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab11b in Genome Data Viewer
    Location:
    7q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15223613..15236754, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14521448..14534589, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18598991..18612132, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene ribosomal protein lateral stalk subunit P1 like 1 Neighboring gene angiopoietin-like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance by transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to acidic pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in constitutive secretory pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in constitutive secretory pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in constitutive secretory pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in melanosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in melanosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of presynaptic dense core granule exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynaptic dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transferrin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-11B
    NP_116006.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032617.2NP_116006.1  ras-related protein Rab-11B

      See identical proteins and their annotated locations for NP_116006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062041
      UniProtKB/Swiss-Prot
      O35509, Q9ET14
      UniProtKB/TrEMBL
      A0A0G2JZR4, A6KQH9
      Related
      ENSRNOP00000010197.4, ENSRNOT00000010197.7
      Conserved Domains (1) summary
      cd01868
      Location:9173
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15223613..15236754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)