Brms1 BRMS1, transcriptional repressor and anoikis regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Brms1provided by RGD
Full Name: BRMS1, transcriptional repressor and anoikis regulatorprovided by RGD
Primary source: RGD:1311057
See related: EnsemblRapid:ENSRNOG00000020117 AllianceGenome:RGD:1311057
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 422.3), Thymus (RPKM 305.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (211775142..211784411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202345766..202355028)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220325352..220334616)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128233 (e-PCR)
- UniSTS:211541

MARC_14863-14864:1010757146:3 (e-PCR)
- UniSTS:267756

RH142943 (e-PCR)
- UniSTS:232190

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of anoikis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: breast cancer metastasis-suppressor 1 homolog

Names: breast cancer metastasis suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009605.1 → NP_001009605.1 breast cancer metastasis-suppressor 1 homolog

See identical proteins and their annotated locations for NP_001009605.1

Status: PROVISIONAL

Source sequence(s)

BC088469

UniProtKB/Swiss-Prot

Q5M7T3

UniProtKB/TrEMBL

A0A8L2QEL2, A6HZ16

Related

ENSRNOP00000027258.6, ENSRNOT00000027258.6

Conserved Domains (1) summary

pfam08598
Location:60 → 177

Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

211775142..211784411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286834.1 → XP_063142904.1 breast cancer metastasis-suppressor 1 homolog isoform X2
XM_063286835.1 → XP_063142905.1 breast cancer metastasis-suppressor 1 homolog isoform X3

UniProtKB/Swiss-Prot

Q5M7T3

UniProtKB/TrEMBL

A6HZ16
XM_063286829.1 → XP_063142899.1 breast cancer metastasis-suppressor 1 homolog isoform X1