Lzts2 leucine zipper tumor suppressor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lzts2provided by RGD
Official Full Name: leucine zipper tumor suppressor 2provided by RGD
Primary source: RGD:1359249
See related: EnsemblRapid:ENSRNOG00000014969 AllianceGenome:RGD:1359249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lapser1
Summary: Involved in negative regulation of fibroblast proliferation and positive regulation of apoptotic process. Located in centrosome; midbody; and mitotic spindle pole. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 56.3), Heart (RPKM 51.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253824073..253837614)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243876665..243888489)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264765256..264776553)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
Title: Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.
LAPSER1 localizes to the centrosomes & midbodies in mitotic cells. LAPSER1 participates in cytokinesis by interacting with p80 katanin, the disruption of which may potentially cause genetic instability and cancer.
Title: LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in primary ureteric bud growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primary ureteric bud growth	ISO Inferred from Sequence Orthology more info
involved_in spindle midzone assembly	IEA Inferred from Electronic Annotation more info
involved_in ureter morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureter morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine zipper putative tumor suppressor 2

Names: protein LAPSER1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014247.2 → NP_001014269.2 leucine zipper putative tumor suppressor 2

See identical proteins and their annotated locations for NP_001014269.2

Status: VALIDATED

Source sequence(s)

BC083580, DN932851, DQ176638

UniProtKB/Swiss-Prot

Q24K74, Q3LUD4

UniProtKB/TrEMBL

F7FLS6

Conserved Domains (2) summary

pfam06818
Location:440 → 636

Fez1; Fez1

pfam15960
Location:503 → 619

DUF4763; Domain of unknown function (DUF4763)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

253824073..253837614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270009.1 → XP_063126079.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/TrEMBL

F7FLS6
XM_017589509.3 → XP_017444998.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/Swiss-Prot

Q24K74, Q3LUD4

UniProtKB/TrEMBL

F7FLS6

Conserved Domains (2) summary

pfam06818
Location:440 → 636

Fez1; Fez1

pfam15960
Location:503 → 619

DUF4763; Domain of unknown function (DUF4763)
XM_017589508.3 → XP_017444997.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/Swiss-Prot

Q24K74, Q3LUD4

UniProtKB/TrEMBL

F7FLS6

Conserved Domains (2) summary

pfam06818
Location:440 → 636

Fez1; Fez1

pfam15960
Location:503 → 619

DUF4763; Domain of unknown function (DUF4763)
XM_006231549.5 → XP_006231611.1 leucine zipper putative tumor suppressor 2 isoform X1

See identical proteins and their annotated locations for XP_006231611.1

UniProtKB/Swiss-Prot

Q24K74, Q3LUD4

UniProtKB/TrEMBL

F7FLS6

Conserved Domains (2) summary

pfam06818
Location:440 → 636

Fez1; Fez1

pfam15960
Location:503 → 619

DUF4763; Domain of unknown function (DUF4763)
XM_063270014.1 → XP_063126084.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/TrEMBL

F7FLS6
XM_006231547.5 → XP_006231609.1 leucine zipper putative tumor suppressor 2 isoform X1

See identical proteins and their annotated locations for XP_006231609.1

UniProtKB/Swiss-Prot

Q24K74, Q3LUD4

UniProtKB/TrEMBL

F7FLS6

Related

ENSRNOP00000042095.4, ENSRNOT00000048843.7

Conserved Domains (2) summary

pfam06818
Location:440 → 636

Fez1; Fez1

pfam15960
Location:503 → 619

DUF4763; Domain of unknown function (DUF4763)