Gnb2 G protein subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnb2provided by RGD
Official Full Name: G protein subunit beta 2provided by RGD
Primary source: RGD:69319
See related: EnsemblRapid:ENSRNOG00000001409 AllianceGenome:RGD:69319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hg2c1
Summary: Enables calcium channel regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of potassium ion transmembrane transport. Located in cell body. Part of protein-containing complex. Is active in parallel fiber to Purkinje cell synapse and synaptic vesicle membrane. Orthologous to human GNB2 (G protein subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 302.8), Spleen (RPKM 292.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (24795505..24800796)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19159002..19164021)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22229079..22234096)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that verexpression of Gbeta2 subunit mimics CaV2.2 kinetic slowing by noradrenaline.
Title: Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.
Gnb2 and Gnb4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons
Title: Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.
analysis of enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma
Title: Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
Data show that the C-terminus of SNAP-25 is a binding target for Gbetagamma necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD.
Title: Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gnb2 (e-PCR), detects polymorphism
- UniSTS:496681

Gnb2 (e-PCR), detects polymorphism
- UniSTS:525225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Names: g protein subunit beta-2; guanine nucleotide binding protein (G protein), beta 2; guanine nucleotide binding protein (G protein), beta polypeptide 2; guanine nucleotide binding protein beta 2 subunit; guanine nucleotide binding protein, beta polypeptide 2; guanine nucleotide-binding protein, beta 2; heterotrimeric guanine nucleotide-binding protein 2c1; transducin beta chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031037.2 → NP_112299.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

See identical proteins and their annotated locations for NP_112299.1

Status: PROVISIONAL

Source sequence(s)

BC065579

UniProtKB/Swiss-Prot

P54313, Q71SU9

UniProtKB/TrEMBL

A6J023, Q45QL6

Related

ENSRNOP00000079960.2, ENSRNOT00000097367.2

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

24795505..24800796

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271695.1 → XP_063127765.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

UniProtKB/Swiss-Prot

P54313, Q71SU9

UniProtKB/TrEMBL

A6J023
XM_039089800.2 → XP_038945728.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

UniProtKB/Swiss-Prot

P54313, Q71SU9

UniProtKB/TrEMBL

A6J023, Q45QL6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_039089799.2 → XP_038945727.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

UniProtKB/Swiss-Prot

P54313, Q71SU9

UniProtKB/TrEMBL

A6J023, Q45QL6

Related

ENSRNOP00000001911.4, ENSRNOT00000001911.6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
XM_039089801.2 → XP_038945729.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

UniProtKB/Swiss-Prot

P54313, Q71SU9

UniProtKB/TrEMBL

A6J023, Q45QL6

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]