Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nek6provided by MGI
Official Full Name: NIMA (never in mitosis gene a)-related expressed kinase 6provided by MGI
Primary source: MGI:MGI:1891638
See related: Ensembl:ENSMUSG00000026749 AllianceGenome:MGI:1891638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300007C09Rik
Summary: Enables protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 28.6), small intestine adult (RPKM 28.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 24.41 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (38314052..38477502)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (38483863..38587490)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
Title: A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
Title: MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
Title: Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
Title: The related murine kinases, Nek6 and Nek7, display distinct patterns of expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144381 (e-PCR)
- UniSTS:233626

Nek6 (e-PCR), detects polymorphism
- UniSTS:507082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase Nek6

Names: NIMA-related expressed kinase 6; never in mitosis A-related kinase 6; nimA-related protein kinase 6

NP_001153103.1

EC 2.7.11.34

NP_067619.1

EC 2.7.11.34

XP_006498272.1

EC 2.7.11.34

XP_006498273.1

EC 2.7.11.34

XP_030107782.1

EC 2.7.11.34

XP_030107783.1

EC 2.7.11.34

XP_030107784.1

EC 2.7.11.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159631.1 → NP_001153103.1 serine/threonine-protein kinase Nek6

See identical proteins and their annotated locations for NP_001153103.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK086700, BY205493

Consensus CDS

CCDS16009.1

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Related

ENSMUSP00000108516.2, ENSMUST00000112895.8

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
NM_021606.3 → NP_067619.1 serine/threonine-protein kinase Nek6

See identical proteins and their annotated locations for NP_067619.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF218847, AK086700

Consensus CDS

CCDS16009.1

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Related

ENSMUSP00000049723.4, ENSMUST00000054234.10

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

38314052..38477502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251924.2 → XP_030107784.1 serine/threonine-protein kinase Nek6 isoform X2

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
XM_030251922.2 → XP_030107782.1 serine/threonine-protein kinase Nek6 isoform X2

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
XM_030251923.2 → XP_030107783.1 serine/threonine-protein kinase Nek6 isoform X2

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
XM_006498210.5 → XP_006498273.1 serine/threonine-protein kinase Nek6 isoform X2

See identical proteins and their annotated locations for XP_006498273.1

UniProtKB/Swiss-Prot

Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70

UniProtKB/TrEMBL

A2ATN9

Conserved Domains (1) summary

cd08228
Location:42 → 309

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
XM_006498209.5 → XP_006498272.1 serine/threonine-protein kinase Nek6 isoform X1

Conserved Domains (1) summary

cd08228
Location:87 → 354

STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6