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    Jmjd1c jumonji domain containing 1C [ Mus musculus (house mouse) ]

    Gene ID: 108829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jmjd1cprovided by MGI
    Official Full Name
    jumonji domain containing 1Cprovided by MGI
    Primary source
    MGI:MGI:1918614
    See related
    Ensembl:ENSMUSG00000037876 AllianceGenome:MGI:1918614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRIP8; Jmjdic; 5430433L24Rik; D630035I23Rik
    Summary
    Predicted to enable chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Acts upstream of or within epithelial cell morphogenesis; male germ-line stem cell population maintenance; and seminiferous tubule development. Predicted to be located in chromatin. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including central nervous system; genitourinary system; heart; inner ear; and limb. Orthologous to human JMJD1C (jumonji domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.3), CNS E14 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Jmjd1c in Genome Data Viewer
    Location:
    10 B5.1; 10 34.85 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (66932189..67092105)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67096351..67256326)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26976 Neighboring gene predicted gene, 53603 Neighboring gene STARR-seq mESC enhancer starr_26978 Neighboring gene VISTA enhancer mm1692 Neighboring gene STARR-seq mESC enhancer starr_26980 Neighboring gene STARR-seq mESC enhancer starr_26981 Neighboring gene predicted gene, 31763 Neighboring gene receptor accessory protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr10:66531454-66531755 Neighboring gene STARR-positive B cell enhancer ABC_E8340 Neighboring gene STARR-seq mESC enhancer starr_26991 Neighboring gene STARR-seq mESC enhancer starr_26992 Neighboring gene STARR-positive B cell enhancer ABC_E10618 Neighboring gene predicted gene, 26359 Neighboring gene STARR-seq mESC enhancer starr_26997 Neighboring gene STARR-seq mESC enhancer starr_26998 Neighboring gene nuclear receptor binding factor 2 Neighboring gene predicted gene, 46200

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression. Xiao F, et al. Stem Cell Reports, 2017 Sep 12. PMID 28826851, Free PMC Article
    2. Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells. Buerger F, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Jul. PMID 28501567
    3. JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. Kuroki S, et al. Biol Reprod, 2013 Oct. PMID 24006281
    4. shRNA screening identifies JMJD1C as being required for leukemia maintenance. Sroczynska P, et al. Blood, 2014 Mar 20. PMID 24501218
    5. MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. Zhu N, et al. J Clin Invest, 2016 Mar 1. PMID 26878175, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JMJD1C promotes lipogenesis to increase hepatic and plasma triglyceride levels, showing its role in metabolic adaption for activation of the lipogenic program in response to feeding/insulin, and its contribution to development of hepatosteatosis resulting in insulin resistance.
      Title: Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis.
    2. Findings support the conclusion that Jmjd1c is dispensable for a Jak2V617F-driven myeloproliferative disease. Also, the strong embryonic Jmjd1c expression in developing muscle tissues suggests additional roles for JMJD1C in organs besides the hematopoietic system.
      Title: Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice.
    3. data suggest that Jmjd1c may participate in mitotic clonal expansion and the activation of the adipogenic transcription program during the induction phase of adipocyte differentiation in 3T3-L1 cells.
      Title: Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells.
    4. JMJD1C ensures efficient generation and maintenance of induced pluripotent stem cells, at least partially through controlling the expression of microRNAs.
      Title: JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression.
    5. These results indicate that JMJD1C has multiple functions during spermatogenesis through interactions with different partners during the spermatogenic stages
      Title: JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.
    6. JMJD1C is an important mediator of MLL-AF9- and HOXA9-driven leukemia stem cell function that is largely dispensable for hematopoietic stem cells function.
      Title: MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.
    7. Data suggest that Jmjd1c is most abundantly expressed in testis in undifferentiated spermatogonia; testes of mutant mice deficient in Jmjd1c frequently contain abnormal seminiferous tubules lacking developmentally immature germ cells.
      Title: JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice.
    8. Depletion of Jmjd1c impairs growth and colony formation of MLL-AF9 cells in vitro as well as establishment of leukemia after transplantation.
      Title: shRNA screening identifies JMJD1C as being required for leukemia maintenance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of cell number IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reproductive senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable JmjC domain-containing histone demethylation protein 2C
    Names
    jumonji domain-containing protein 1C
    NP_001229325.1
    NP_997104.2
    XP_006513098.1
    XP_006513100.1
    XP_006513103.1
    XP_006513104.1
    XP_006513105.1
    XP_006513107.1
    XP_030100665.1
    XP_030100667.1
    XP_030100670.1
    XP_030100671.1
    XP_030100672.1
    XP_030100674.1
    XP_030100677.1
    XP_036011379.1
    XP_036011380.1
    XP_036011381.1
    XP_036011382.1
    XP_036011383.1
    XP_036011384.1
    XP_036011385.1
    XP_036011386.1
    XP_036011387.1
    XP_036011388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242396.1 → NP_001229325.1  probable JmjC domain-containing histone demethylation protein 2C isoform 2

      See identical proteins and their annotated locations for NP_001229325.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks a single internal aa compared to isoform 1.
      Source sequence(s)
      AC155712, AC156272, AK082106, AK085500, BC054559, BP761712, CD578529
      Consensus CDS
      CCDS56708.1
      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Related
      ENSMUSP00000133700.2, ENSMUST00000173689.8
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    2. NM_207221.3 → NP_997104.2  probable JmjC domain-containing histone demethylation protein 2C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC155712, AC156272
      Consensus CDS
      CCDS56707.1
      UniProtKB/TrEMBL
      A0A0A0MQ98
      Related
      ENSMUSP00000056227.10, ENSMUST00000051446.16
      Conserved Domains (2) summary
      smart00558
      Location:2286 → 2340
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      cl21464
      Location:2372 → 2471
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      66932189..67092105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155486.1 → XP_036011379.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    2. XM_036155494.1 → XP_036011387.1  probable JmjC domain-containing histone demethylation protein 2C isoform X7

      Conserved Domains (3) summary
      smart00558
      Location:2000 → 2054
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:779 → 973
      AvrE; Pathogenicity factor
      cl40423
      Location:2086 → 2185
      cupin_RmlC-like; RmlC-like cupin superfamily

    3. XM_036155489.1 → XP_036011382.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    4. XM_036155492.1 → XP_036011385.1  probable JmjC domain-containing histone demethylation protein 2C isoform X6

      Conserved Domains (3) summary
      smart00558
      Location:2038 → 2092
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:817 → 1011
      AvrE; Pathogenicity factor
      cl40423
      Location:2124 → 2223
      cupin_RmlC-like; RmlC-like cupin superfamily

    5. XM_036155487.1 → XP_036011380.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    6. XM_036155490.1 → XP_036011383.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    7. XM_036155493.1 → XP_036011386.1  probable JmjC domain-containing histone demethylation protein 2C isoform X6

      Conserved Domains (3) summary
      smart00558
      Location:2038 → 2092
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:817 → 1011
      AvrE; Pathogenicity factor
      cl40423
      Location:2124 → 2223
      cupin_RmlC-like; RmlC-like cupin superfamily

    8. XM_030244805.2 → XP_030100665.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    9. XM_030244817.2 → XP_030100677.1  probable JmjC domain-containing histone demethylation protein 2C isoform X7

      Conserved Domains (3) summary
      smart00558
      Location:2000 → 2054
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:779 → 973
      AvrE; Pathogenicity factor
      cl40423
      Location:2086 → 2185
      cupin_RmlC-like; RmlC-like cupin superfamily

    10. XM_030244810.2 → XP_030100670.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    11. XM_030244814.2 → XP_030100674.1  probable JmjC domain-containing histone demethylation protein 2C isoform X6

      Conserved Domains (3) summary
      smart00558
      Location:2038 → 2092
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:817 → 1011
      AvrE; Pathogenicity factor
      cl40423
      Location:2124 → 2223
      cupin_RmlC-like; RmlC-like cupin superfamily

    12. XM_006513042.5 → XP_006513105.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      See identical proteins and their annotated locations for XP_006513105.1

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    13. XM_006513044.5 → XP_006513107.1  probable JmjC domain-containing histone demethylation protein 2C isoform X7

      Conserved Domains (3) summary
      smart00558
      Location:2000 → 2054
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:779 → 973
      AvrE; Pathogenicity factor
      cl40423
      Location:2086 → 2185
      cupin_RmlC-like; RmlC-like cupin superfamily

    14. XM_030244807.2 → XP_030100667.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    15. XM_030244812.2 → XP_030100672.1  probable JmjC domain-containing histone demethylation protein 2C isoform X6

      Conserved Domains (3) summary
      smart00558
      Location:2038 → 2092
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:817 → 1011
      AvrE; Pathogenicity factor
      cl40423
      Location:2124 → 2223
      cupin_RmlC-like; RmlC-like cupin superfamily

    16. XM_006513041.4 → XP_006513104.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      See identical proteins and their annotated locations for XP_006513104.1

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    17. XM_036155491.1 → XP_036011384.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    18. XM_036155488.1 → XP_036011381.1  probable JmjC domain-containing histone demethylation protein 2C isoform X4

      UniProtKB/Swiss-Prot
      E9QMM8, Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9
      Conserved Domains (3) summary
      smart00558
      Location:2106 → 2160
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:885 → 1079
      AvrE; Pathogenicity factor
      cl40423
      Location:2192 → 2291
      cupin_RmlC-like; RmlC-like cupin superfamily

    19. XM_006513035.4 → XP_006513098.1  probable JmjC domain-containing histone demethylation protein 2C isoform X1

      UniProtKB/TrEMBL
      G3UZM1
      Related
      ENSMUSP00000134551.2, ENSMUST00000174408.8
      Conserved Domains (3) summary
      smart00558
      Location:2287 → 2341
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:1066 → 1260
      AvrE; Pathogenicity factor
      cl21464
      Location:2373 → 2472
      cupin_like; Conserved domain found in cupin and related proteins

    20. XM_006513040.4 → XP_006513103.1  probable JmjC domain-containing histone demethylation protein 2C isoform X3

      Conserved Domains (3) summary
      smart00558
      Location:2219 → 2273
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:998 → 1192
      AvrE; Pathogenicity factor
      cl21464
      Location:2305 → 2404
      cupin_like; Conserved domain found in cupin and related proteins

    21. XM_006513037.4 → XP_006513100.1  probable JmjC domain-containing histone demethylation protein 2C isoform X2

      Conserved Domains (3) summary
      smart00558
      Location:2249 → 2303
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:1028 → 1222
      AvrE; Pathogenicity factor
      cl21464
      Location:2335 → 2434
      cupin_like; Conserved domain found in cupin and related proteins

    22. XM_030244811.1 → XP_030100671.1  probable JmjC domain-containing histone demethylation protein 2C isoform X5

      Conserved Domains (3) summary
      smart00558
      Location:2052 → 2106
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:831 → 1025
      AvrE; Pathogenicity factor
      cl40423
      Location:2138 → 2237
      cupin_RmlC-like; RmlC-like cupin superfamily

    23. XM_036155495.1 → XP_036011388.1  probable JmjC domain-containing histone demethylation protein 2C isoform X7

      Conserved Domains (3) summary
      smart00558
      Location:2000 → 2054
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam11725
      Location:779 → 973
      AvrE; Pathogenicity factor
      cl40423
      Location:2086 → 2185
      cupin_RmlC-like; RmlC-like cupin superfamily

    RNA

    1. XR_001779409.2 RNA Sequence

    2. XR_001779410.2 RNA Sequence

    3. XR_001779408.2 RNA Sequence

    4. XR_004936032.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZK6.3 GenPept UniProtKB/Swiss-Prot:Q69ZK6

    Gene LinkOut

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    Chemical Information
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    Research Materials
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