Hdac6 histone deacetylase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac6provided by MGI
Official Full Name: histone deacetylase 6provided by MGI
Primary source: MGI:MGI:1333752
See related: Ensembl:ENSMUSG00000031161 AllianceGenome:MGI:1333752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hd6; Sfc6; Hdac5; mHDA2
Summary: Enables cytoskeletal protein binding activity; protein lysine deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of metabolic process; protein deacetylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; neuron projection morphogenesis; and protein modification process. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; gut gland; lung; and metanephros. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 65.5), whole brain E14.5 (RPKM 26.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.58 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7796355..7814284, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7930116..7948047, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
Title: HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
Histone deacetylase 6 controls cardiac fibrosis and remodelling through the modulation of TGF-beta1/Smad2/3 signalling in post-infarction mice.
Title: Histone deacetylase 6 controls cardiac fibrosis and remodelling through the modulation of TGF-β1/Smad2/3 signalling in post-infarction mice.
Downregulation of HDAC6 mitigates lung ischemia/reperfusion injury depending on activation of Nrf2/HO-1 signaling pathway and inactivation of ERK/NF-kappaB signaling pathway.
Title: Downregulation of HDAC6 mitigates lung ischemia/reperfusion injury depending on activation of Nrf2/HO-1 signaling pathway and inactivation of ERK/NF-κB signaling pathway.
ClassIIb histone deacetylase participates in perioperative neurocognitive disorders in elderly mice via HSP90/GR signaling pathway.
Title: ClassIIb histone deacetylase participates in perioperative neurocognitive disorders in elderly mice via HSP90/GR signaling pathway.
HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90-HSF1 pathway.
Title: HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90-HSF1 pathway.
Lack of effect from genetic deletion of Hdac6 in a humanized mouse model of CMT2D.
Title: Lack of effect from genetic deletion of Hdac6 in a humanized mouse model of CMT2D.
Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice.
Title: Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice.
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Title: HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Title: Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia.
Title: The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia.

Submit: New GeneRIF Correction See all GeneRIFs (162)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF006603 (e-PCR)
- UniSTS:186168

RH126845 (e-PCR)
- UniSTS:209496

DXImx16 (e-PCR), detects polymorphism
- UniSTS:186200

DXImx17 (e-PCR), detects polymorphism
- UniSTS:186201

OMM5169 (e-PCR)
- UniSTS:465784

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
NOT enables acetylspermidine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables histone H3K14 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K12 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K5 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K8 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin deacetylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables tubulin deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tubulin deacetylase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Hsp90 deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aggresome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to topologically incorrect protein	ISO Inferred from Sequence Orthology more info
involved_in cilium disassembly	IEA Inferred from Electronic Annotation more info
involved_in cilium disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte enucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of aggrephagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of aggrephagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
NOT involved_in polyamine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyubiquitinated misfolded protein transport	IEA Inferred from Electronic Annotation more info
involved_in polyubiquitinated misfolded protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholangiocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type 2 mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IEA Inferred from Electronic Annotation more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex disassembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to misfolded protein	ISO Inferred from Sequence Orthology more info
NOT involved_in spermidine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tubulin deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in type 2 mitophagy	IEA Inferred from Electronic Annotation more info
involved_in type 2 mitophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	IEA Inferred from Electronic Annotation more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: histone deacetylase 6

Names: histone deacetylase 5; histone deacetylase mHDA2; protein deacetylase HDAC6; scurfy candidate 6; tubulin-lysine deacetylase HDAC6

NP_001123888.1

EC 3.5.1.98

NP_001398533.1

EC 3.5.1.98

NP_001398535.1

EC 3.5.1.98

NP_001398536.1

EC 3.5.1.98

NP_001398537.1

EC 3.5.1.98

NP_001398541.1

EC 3.5.1.98

NP_034543.3

EC 3.5.1.98

XP_017173878.1

EC 3.5.1.98

XP_036017717.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130416.2 → NP_001123888.1 histone deacetylase 6 isoform 2

See identical proteins and their annotated locations for NP_001123888.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670169

Consensus CDS

CCDS40845.1

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5

Related

ENSMUSP00000111306.2, ENSMUST00000115642.8

Conserved Domains (3) summary

cd10003
Location:484 → 834

HDAC6-dom2; Histone deacetylase 6, domain 2

pfam02148
Location:1067 → 1129

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl17011
Location:98 → 434

Arginase_HDAC; Arginase-like and histone-like hydrolases
NM_001411604.1 → NP_001398533.1 histone deacetylase 6 isoform 1

Status: VALIDATED

Source sequence(s)

AL670169

UniProtKB/TrEMBL

Q3U4Q5
NM_001411606.1 → NP_001398535.1 histone deacetylase 6 isoform 2

Status: VALIDATED

Source sequence(s)

AL670169

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5
NM_001411607.1 → NP_001398536.1 histone deacetylase 6 isoform 2

Status: VALIDATED

Source sequence(s)

AL670169

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5
NM_001411608.1 → NP_001398537.1 histone deacetylase 6 isoform 3

Status: VALIDATED

Source sequence(s)

AL670169

UniProtKB/TrEMBL

Q3U4Q5
NM_001411612.1 → NP_001398541.1 histone deacetylase 6 isoform 4

Status: VALIDATED

Source sequence(s)

AL670169

UniProtKB/TrEMBL

Q3U4Q5
NM_010413.4 → NP_034543.3 histone deacetylase 6 isoform 2

See identical proteins and their annotated locations for NP_034543.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670169

Consensus CDS

CCDS40845.1

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5

Related

ENSMUSP00000033501.9, ENSMUST00000033501.15

Conserved Domains (3) summary

cd10003
Location:484 → 834

HDAC6-dom2; Histone deacetylase 6, domain 2

pfam02148
Location:1067 → 1129

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl17011
Location:98 → 434

Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

NR_177433.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670169
NR_177434.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670169

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

7796355..7814284 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318389.3 → XP_017173878.1 histone deacetylase 6 isoform X1

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5

Conserved Domains (3) summary

cd10003
Location:484 → 834

HDAC6-dom2; Histone deacetylase 6, domain 2

pfam02148
Location:1067 → 1129

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl17011
Location:98 → 434

Arginase_HDAC; Arginase-like and histone-like hydrolases
XM_036161824.1 → XP_036017717.1 histone deacetylase 6 isoform X1

UniProtKB/Swiss-Prot

B1AUA6, Q9Z2V5

UniProtKB/TrEMBL

Q3U4Q5

Conserved Domains (3) summary

cd10003
Location:484 → 834

HDAC6-dom2; Histone deacetylase 6, domain 2

pfam02148
Location:1067 → 1129

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl17011
Location:98 → 434

Arginase_HDAC; Arginase-like and histone-like hydrolases