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    SHO1 osmosensor SHO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHO1
    Official Full Name
    osmosensor SHO1
    Primary source
    SGD:S000000920
    Locus tag
    YER118C
    See related
    AllianceGenome:SGD:S000000920; FungiDB:YER118C; VEuPathDB:YER118C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SSU81
    Summary
    Enables MAP-kinase scaffold activity and osmosensor activity. Involved in establishment of cell polarity; osmosensory signaling pathway via Sho1 osmosensor; and signal transduction involved in filamentous growth. Located in cellular bud neck; mating projection tip; and plasma membrane. Part of HICS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHO1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (397952..399055, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX8 Neighboring gene ribosomal 60S subunit protein L23B Neighboring gene aspartate/glutamate transporter Neighboring gene phosphatidylinositol-binding protein SCS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-selective Characterization of Src Homology 3 Domain Molecular Recognition with Cyanophenylalanine Infrared Probes. Horness RE, et al. Anal Methods, 2015. PMID 26491469, Free PMC Article
    2. Candidate osmosensors from Candida utilis and Kluyveromyces lactis: structural and functional homology to the Sho1p putative osmosensor from Saccharomyces cerevisiae. Siderius M, et al. Biochim Biophys Acta, 2000 Dec 15. PMID 11118628
    3. Signal transduction: molecular monogamy. Endy D, et al. Nature, 2003 Dec 11. PMID 14668845
    4. Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains. Horness RE, et al. J Am Chem Soc, 2016 Feb 3. PMID 26784847, Free PMC Article
    5. Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast. Marles JA, et al. Mol Cell, 2004 Jun 18. PMID 15200958

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sho1-Opy2 interaction enhances the activation of Pbs2 by Ste11, but not Hog1 by Pbs2. Chemical crosslinking and mutational analyses revealed that the cytoplasmic ends of Sho1 TM1 and Opy2 TM also interact with each other, defining the Sho1-Opy2 binding site 2 (BS2).
      Title: Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae.
    2. Sho1 essential for survival under mechanical pressure.
      Title: SCWISh network is essential for survival under mechanical pressure.
    3. Fps1 binds the SH3 domain of Sho1 through its N-terminus domain and is involved in the positive regulation of Sho1p function.
      Title: A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae.
    4. Data showed that Msb2p had a function in cell polarization through the adaptor protein Sho1p that Hkr1p did not.
      Title: The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.
    5. Hkr1 and Msb2 individually form a complex with Sho1, and, upon high external osmolarity stress, appear to induce Sho1 to generate an intracellular signal
      Title: Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.
    6. study showed that the membrane-bound osmosensor Sho1 is phosphorylated by Hog1 & that phosphorylation occurs on Ser-166; findings reveal a novel phosphorylation-dependent feedback loop leading to diminished cellular responses to an osmotic-stress stimulus
      Title: A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.
    7. Sho1p plays role in signal transduction pathway.
      Title: Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables osmosensor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction involved in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HICS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    osmosensor SHO1
    NP_011043.1
    • Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      397952..399055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179008.1 → NP_011043.1  TPA: osmosensor SHO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5VHP4, D3DM24, E7KBW4, E7KMS3, E7LTJ6, E7QE10, P40073
      UniProtKB/TrEMBL
      N1P521
      Conserved Domains (1) summary
      cd11855
      Location:304 → 358
      SH3_Sho1p; Src homology 3 domain of High osmolarity signaling protein Sho1p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40073.1

    Gene LinkOut

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