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    PHD1 Phd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHD1
    Official Full Name
    Phd1p
    Primary source
    SGD:S000001526
    Locus tag
    YKL043W
    See related
    AllianceGenome:SGD:S000001526; FungiDB:YKL043W; VEuPathDB:YKL043W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity. Involved in positive regulation of pseudohyphal growth and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHD1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (356748..357848)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA primase subunit PRI2 Neighboring gene Mmo1p Neighboring gene Spc42p Neighboring gene ESCRT-III subunit protein VPS24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution and phylogenetic relationships of APSES proteins from Hemiascomycetes. Ramírez-Zavala B, et al. FEMS Yeast Res, 2008 Jun. PMID 18355269
    2. Enhancement of superficial pseudohyphal growth by overexpression of the SFG1 gene in yeast Saccharomyces cerevisiae. Fujita A, et al. Gene, 2005 Dec 19. PMID 16289536
    3. Enhanced expression of genes involved in initial xylose metabolism and the oxidative pentose phosphate pathway in the improved xylose-utilizing Saccharomyces cerevisiae through evolutionary engineering. Zha J, et al. J Ind Microbiol Biotechnol, 2014 Jan. PMID 24113893
    4. Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Gimeno CJ, et al. Mol Cell Biol, 1994 Mar. PMID 8114741, Free PMC Article
    5. Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae. Chandarlapaty S, et al. Mol Cell Biol, 1998 May. PMID 9566907, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It was shown that Phd1 is an unstable protein whose degradation is initiated through phosphorylation by Cdk8 of the RNA polymerase II mediator subcomplex.
      Title: Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phd1p
    NP_012881.1
    • Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      356748..357848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179609.1 → NP_012881.1  TPA: Phd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXP3, P36093, Q2VQ88
      UniProtKB/TrEMBL
      A6ZZS2, B3LR45, C8ZCC7, E9P975, G2WHY8, N1P0A6, Q2VQ91, Q2VQ92
      Conserved Domains (1) summary
      pfam04383
      Location:205 → 285
      KilA-N; KilA-N domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36093.1

    Gene LinkOut

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