ATG2 Atg2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG2
Official Full Name: Atg2p
Primary source: SGD:S000005186
Locus tag: YNL242W
See related: AllianceGenome:SGD:S000005186; FungiDB:YNL242W; VEuPathDB:YNL242W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APG2; AUT8; SPO72
Summary: Enables phosphatidylinositol-3-phosphate binding activity. Involved in autophagy of mitochondrion; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in phagophore and phagophore assembly site. Orthologous to human ATG2A (autophagy related 2A) and ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATG2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (191324..196102)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics.
Title: Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics.
The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae.
Title: The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae.
Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes.
Title: Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes.
Atg2: A novel phospholipid transfer protein that mediates de novo autophagosome biogenesis
Title: Atg2: A novel phospholipid transfer protein that mediates de novo autophagosome biogenesis.
Assembly of the Atg9-Atg2-Atg18 complex is important to establish phagophore-endoplasmic reticulum (ER) contact sites.
Title: Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores.
Atg2-Atg18 complex tethers the preautophagosomal structure to the endoplasmic reticulum to initiate membrane expansion during autophagosome formation.
Title: The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation.
The Atg2-Atg18 complex and Atg9 localized to the edge of the IM, appearing as two or three dots, in close proximity to the endoplasmic reticulum exit sites.
Title: Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
effective targeting of Atg2 to the PAS can compensate for loss of Atg18 function in autophagy
Title: Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.
Atg18 forms a complex with Atg2 irrespective of PtdIns(3)P binding, associates tightly to autophagic membranes by interacting with PtdIns(3)P, and plays an essential role.
Title: The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in pexophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Atg2p

NP_014157.1

Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

191324..196102

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183080.1 → NP_014157.1 TPA: Atg2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014157.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZRK1, D6W0V1, P53855

Conserved Domains (2) summary

pfam09333
Location:1489 → 1586

ATG_C; Autophagy-related protein C terminal domain

pfam13329
Location:784 → 921

ATG2_CAD; Autophagy-related protein 2 CAD motif