Pcdhgc4 protocadherin gamma subfamily C, 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdhgc4provided by MGI
Official Full Name: protocadherin gamma subfamily C, 4provided by MGI
Primary source: MGI:MGI:1935203
See related: Ensembl:ENSMUSG00000023036 AllianceGenome:MGI:1935203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within negative regulation of neuron apoptotic process and synapse organization. Located in membrane. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PCDHGC4 (protocadherin gamma subfamily C, 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 45.5), CNS E18 (RPKM 44.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 19.68 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (37948132..37974926)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (37815079..37841873)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The clustered gamma protocadherin PcdhgammaC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.
Title: The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.
Results show that some gamma-Pcdh functions do not require molecular diversity, and confirm that at least some gamma-Pcdh isoforms have unique roles. These data suggest that the regulation of neuronal survival may require novel mechanisms of cPcdh interaction and/ or signaling involving gammaC4.
Title: CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synapse organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protocadherin gamma-C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033582.2 → NP_291060.1 protocadherin gamma-C4 precursor

See identical proteins and their annotated locations for NP_291060.1

Status: PROVISIONAL

Source sequence(s)

BC064808

Consensus CDS

CCDS29193.1

UniProtKB/TrEMBL

Q3UTF9, Q91XX0

Related

ENSMUSP00000068846.7, ENSMUST00000066140.13

Conserved Domains (3) summary

cd11304
Location:249 → 349

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:33 → 114

Cadherin_2; Cadherin-like

pfam15974
Location:820 → 914

Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region