U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF157 zinc finger protein 157 [ Homo sapiens (human) ]

    Gene ID: 7712, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF157provided by HGNC
    Official Full Name
    zinc finger protein 157provided by HGNC
    Primary source
    HGNC:HGNC:12942
    See related
    Ensembl:ENSG00000147117 MIM:300024; AllianceGenome:HGNC:12942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF22
    Summary
    This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZNF157 in Genome Data Viewer
    Location:
    Xp11.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47370578..47414498)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (46780444..46824376)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47229977..47273897)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 785, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47171435-47171935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20803 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47176727-47177364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29589 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:47181311-47181880 Neighboring gene U6 spliceosomal RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29592 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47240535-47241034 Neighboring gene UBX domain protein 4 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11C Neighboring gene nucleophosmin 1 pseudogene 49 Neighboring gene zinc finger protein 41 Neighboring gene uncharacterized LOC124900499

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning and characterization of a novel zinc finger gene in Xp11.2. Derry JM, et al. Genomics, 1995 Nov 20. PMID 8586441
    2. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. Thiselton DL, et al. Genomics, 2002 Apr. PMID 11944989
    3. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Macgregor S, et al. Hum Mol Genet, 2010 Jul 1. PMID 20395239, Free PMC Article
    4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
    5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 157
    Names
    zinc finger protein 22
    zinc finger protein HZF22

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003446.4 → NP_003437.2  zinc finger protein 157

      See identical proteins and their annotated locations for NP_003437.2

      Status: REVIEWED

      Source sequence(s)
      AL590223, AL591503
      Consensus CDS
      CCDS14278.1
      UniProtKB/Swiss-Prot
      P51786, Q96LE9
      Related
      ENSP00000366273.4, ENST00000377073.4
      Conserved Domains (6) summary
      smart00349
      Location:27 → 87
      KRAB; krueppel associated box
      COG5048
      Location:159 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:470 → 492
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:345 → 367
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      47370578..47414498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      46780444..46824376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51786.2 GenPept UniProtKB/Swiss-Prot:P51786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous