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    KIF3A kinesin family member 3A [ Homo sapiens (human) ]

    Gene ID: 11127, updated on 10-Dec-2024

    Summary

    Official Symbol
    KIF3Aprovided by HGNC
    Official Full Name
    kinesin family member 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:6319
    See related
    Ensembl:ENSG00000131437 MIM:604683; AllianceGenome:HGNC:6319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLA10; KLP-20
    Summary
    Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole; centrosome; and spindle microtubule. Part of kinesin II complex. Biomarker of silicosis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 20.7), testis (RPKM 8.8) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KIF3A in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132688812..132737546, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133208481..133257281, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132028323..132073238, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132000651-132001178 Neighboring gene interleukin 13 Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23096 Neighboring gene septin 8 Neighboring gene cyclin I family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16337 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150138-132150638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150639-132151139 Neighboring gene sosondowah ankyrin repeat domain family member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (21 hits/1261 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of kinesin family member 3A (KIF3A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Changes of IP7 intracellular levels affect HIV-1 Gag release through modulation of AP3B1 and Kif3A interaction PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables microtubule binding  
    enables microtubule motor activity  
    enables plus-end-directed microtubule motor activity PubMed 
    enables protein binding PubMed 
    enables protein phosphatase binding PubMed 
    enables small GTPase binding PubMed 
    enables spectrin binding PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport  
    involved_in centriole-centriole cohesion  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in microtubule anchoring at centrosome  
    involved_in organelle organization PubMed 
    involved_in plus-end-directed vesicle transport along microtubule PubMed 
    involved_in protein localization to cell junction PubMed 
    involved_in protein transport PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm  
    located_in centriole PubMed 
    located_in centrosome PubMed 
    located_in ciliary tip  
    located_in cilium  
    located_in cilium  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in extracellular exosome PubMed 
    part_of kinesin II complex PubMed 
    part_of kinesin complex  
    is_active_in microtubule  
    located_in microtubule cytoskeleton PubMed 
    colocalizes_with spindle microtubule PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF3A
    Names
    kinesin family protein 3A
    microtubule plus end-directed kinesin motor 3A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300791.2 → NP_001287720.1  kinesin-like protein KIF3A isoform 1

      See identical proteins and their annotated locations for NP_001287720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004039, AK295089, AW086059, BC045542
      Consensus CDS
      CCDS75296.1
      UniProtKB/TrEMBL
      B4DHG8, E9PES4
      Related
      ENSP00000385808.1, ENST00000403231.6
      Conserved Domains (2) summary
      TIGR02168
      Location:450 → 616
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    2. NM_001300792.2 → NP_001287721.1  kinesin-like protein KIF3A isoform 2

      See identical proteins and their annotated locations for NP_001287721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB209780, AC004039, AW086059, BC045542
      Consensus CDS
      CCDS75295.1
      UniProtKB/TrEMBL
      B4DHG8, J3KPF9
      Related
      ENSP00000368009.1, ENST00000378735.5
      Conserved Domains (2) summary
      TIGR02168
      Location:358 → 592
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    3. NM_007054.7 → NP_008985.3  kinesin-like protein KIF3A isoform 3

      See identical proteins and their annotated locations for NP_008985.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB209780, AC004039, AK313359, AW086059, BC020890
      Consensus CDS
      CCDS34235.1
      UniProtKB/Swiss-Prot
      A8MSW9, Q59EN1, Q86XE9, Q9Y496, Q9Y6V4
      UniProtKB/TrEMBL
      B4DHG8
      Related
      ENSP00000368020.3, ENST00000378746.8
      Conserved Domains (2) summary
      TIGR02168
      Location:340 → 589
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      132688812..132737546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008996.3 → XP_016864485.1  kinesin-like protein KIF3A isoform X2

      UniProtKB/TrEMBL
      B4DHG8
    2. XM_006714526.5 → XP_006714589.1  kinesin-like protein KIF3A isoform X1

      UniProtKB/TrEMBL
      B4DHG8
      Conserved Domains (4) summary
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:20 → 345
      Kinesin; Kinesin motor domain
      cd16269
      Location:597 → 608
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:448 → 611
      GBP_C; Guanylate-binding protein, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      133208481..133257281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351517.1 → XP_054207492.1  kinesin-like protein KIF3A isoform X1

      UniProtKB/TrEMBL
      B4DHG8
    2. XM_054351518.1 → XP_054207493.1  kinesin-like protein KIF3A isoform X2

      UniProtKB/TrEMBL
      B4DHG8
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