ECM4 S-glutathionyl-(chloro)hydroquinone reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ECM4
Official Full Name: S-glutathionyl-(chloro)hydroquinone reductase
Primary source: SGD:S000001784
Locus tag: YKR076W
See related: AllianceGenome:SGD:S000001784; FungiDB:YKR076W; VEuPathDB:YKR076W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GTO2
Summary: Enables glutathione transferase activity. Involved in glutathione metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECM4 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (582283..583395)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ScECM4 possessed a tremendously elongated loop between strand beta2 and helix alpha2 involved in the dimer interface, two more spiral turns in helix alpha5 that make it 45 A long and an additional helix alpha5' with two helical turns.
Title: Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones.
act as 1-Cys thiol transferases
Title: Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-glutathionyl-(chloro)hydroquinone reductase

NP_013002.3

EC 1.8.5.1

EC 2.5.1.18

S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

582283..583395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179866.3 → NP_013002.3 TPA: S-glutathionyl-(chloro)hydroquinone reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013002.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXD6, P36156

UniProtKB/TrEMBL

A7A035, B3LRF0, C7GXD4, C8ZCN7, G2WIA3

Conserved Domains (1) summary

COG0435
Location:1 → 370

ECM4; Glutathionyl-hydroquinone reductase [Energy production and conversion]