SPE1 ornithine decarboxylase SPE1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPE1
Official Full Name: ornithine decarboxylase SPE1
Primary source: SGD:S000001667
Locus tag: YKL184W
See related: AllianceGenome:SGD:S000001667; FungiDB:YKL184W; VEuPathDB:YKL184W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ORD1; SPE10
Summary: Enables ornithine decarboxylase activity. Involved in pantothenate biosynthetic process and putrescine biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to several human genes including AZIN1 (antizyme inhibitor 1) and ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SPE1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (96757..98157)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The molecular weight of the ODC:AZ complex is 90 kDa, which indicates a one to one stoichiometric binding of AZ and ODC in vitro.
Title: Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex.
Increased rates of ornithine decarboxylase turnover in an rpn10Delta mutant in which the degradation of certain ubiquitinated substrates is impaired.
Title: A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in putrescine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process from ornithine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ornithine decarboxylase SPE1

NP_012737.1

EC 4.1.1.17

Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

96757..98157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179750.1 → NP_012737.1 TPA: ornithine decarboxylase SPE1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012737.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX16, P08432

UniProtKB/TrEMBL

A6ZZE1, N1P128

Conserved Domains (1) summary

cd00622
Location:84 → 460

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase