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    DOT5 thioredoxin peroxidase DOT5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854805, updated on 9-Dec-2024

    Summary

    Official Symbol
    DOT5
    Official Full Name
    thioredoxin peroxidase DOT5
    Primary source
    SGD:S000001272
    Locus tag
    YIL010W
    See related
    AllianceGenome:SGD:S000001272; FungiDB:YIL010W; VEuPathDB:YIL010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thioredoxin peroxidase activity. Involved in cell redox homeostasis and cellular response to oxidative stress. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See DOT5 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (334882..335529)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tir3p Neighboring gene telomerase subunit EST3 Neighboring gene tRNA-Asp

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thioredoxin peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thioredoxin-dependent peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin peroxidase DOT5
    NP_012255.3
    • Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      334882..335529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179360.3NP_012255.3  TPA: thioredoxin peroxidase DOT5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012255.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVR9, P40553
      UniProtKB/TrEMBL
      A6ZVQ7, B3LTL9, C7GJI1, C8ZAN9, G2WGD5, N1P967
      Conserved Domains (1) summary
      cd03017
      Location:67207
      PRX_BCP; Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing ...