OSH3 oxysterol-binding protein related protein OSH3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: OSH3
Official Full Name: oxysterol-binding protein related protein OSH3
Primary source: SGD:S000001115
Locus tag: YHR073W
See related: AllianceGenome:SGD:S000001115; FungiDB:YHR073W; VEuPathDB:YHR073W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables lipid binding activity and sterol transfer activity. Involved in several processes, including ER to Golgi ceramide transport; invasive growth in response to glucose limitation; and karyogamy involved in conjugation with cellular fusion. Acts upstream of or within reticulophagy. Located in cortical endoplasmic reticulum and plasma membrane. Orthologous to human OSBPL3 (oxysterol binding protein like 3); OSBPL6 (oxysterol binding protein like 6); and OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See OSH3 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (242582..245572)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structures of the PH domain and ORD (OSBP-related domain) of yeast Osh3 in apo-form or in complex with phosphatidylinositol 4-phosphate.
Title: Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins.
Crystallization and preliminary X-ray crystallographic analysis of the oxysterol-binding protein Osh3 from Saccharomyces cerevisiae
Title: Crystallization and preliminary X-ray crystallographic analysis of the oxysterol-binding protein Osh3 from Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol transfer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ER to Golgi ceramide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in invasive growth in response to glucose limitation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in karyogamy involved in conjugation with cellular fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reticulophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sterol transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: oxysterol-binding protein related protein OSH3

NP_011940.1

Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

242582..245572

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179203.1 → NP_011940.1 TPA: oxysterol-binding protein related protein OSH3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011940.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL23, P38713

UniProtKB/TrEMBL

A6ZSY0, B3LSJ1, C7GWT5, C8Z9L4, N1P4J5

Conserved Domains (2) summary

cd13289
Location:223 → 313

PH_Osh3p_yeast; Yeast oxysterol binding protein homolog 3 Pleckstrin homology (PH) domain

pfam01237
Location:642 → 982

Oxysterol_BP; Oxysterol-binding protein