NMA2 nicotinamide-nucleotide adenylyltransferase NMA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NMA2
Official Full Name: nicotinamide-nucleotide adenylyltransferase NMA2
Primary source: SGD:S000003242
Locus tag: YGR010W
See related: AllianceGenome:SGD:S000003242; FungiDB:YGR010W; VEuPathDB:YGR010W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nicotinamide-nucleotide adenylyltransferase activity. Involved in NAD biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to several human genes including NMNAT1 (nicotinamide nucleotide adenylyltransferase 1) and NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NMA2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (511545..512732)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD(+) biosynthetic enzymes in Saccharomyces cerevisiae.
Title: N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD(+) biosynthetic enzymes in Saccharomyces cerevisiae.
The yeast homologs of NMNAT (NMA1/2) and other genes in the NAD+ salvage pathway protect cells through a mechanism involving the targeting of toxic misfolded and oligomerized proteins for degradation and clearance.
Title: NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide-nucleotide adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinamide-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide-nucleotide adenylyltransferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables nicotinate-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nicotinamide-nucleotide adenylyltransferase NMA2

NP_011524.1

EC 2.7.7.1

EC 2.7.7.18

Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

511545..512732

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181139.1 → NP_011524.1 TPA: nicotinamide-nucleotide adenylyltransferase NMA2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011524.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUE7, P53204

UniProtKB/TrEMBL

A6ZV02, B3LIK6, C7GK80, C8Z8Q4, G2WEA3, N1P220

Conserved Domains (1) summary

cd09286
Location:160 → 380

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic